The present study was aimed to evaluate the role of curcumin (CMN) against
cytotoxicity of cadmium chloride. Thirty adult male albino mice 3 months old
and20-25 grams body weight, were caged into six equal groups. Mice were
injected, i.p with 50 mg CMN/kg and/or 0.67 mg CdCl2/kg b.w for 96h,
separately and alternated. The alternated trials were continued for consecutive
8 days.
Results appeared that mice injected with cadmium had significant higher
frequency of chromosomal aberrations as fragments, centric fusion, gaps,
stickiness and aneuploidy. Also, CdCl2 appeared sperm hummer, without
hook, banana and amorphous abnormalities. The administration of CMN
improved the frequency of the chromosomal aberrations and sperm
abnormalities induced by CdCl2. The administration of CMN after CdCl2
protects the body from cytotoxicity arising from CdCl2 as well as normal
sperm values were recorded. The administration of curcumin before CdCl2
injection did not improve the CdCl2 effect. It could be concluded that the
employed dose of CMN protects the body from cytotoxicity arising.