Chronic exposure to heavy metals including lead and cadmium remains a serious problem for humanity. The current study aims to evaluate the impact of exposure to lead (Pb) and cadmium (Cd) on liver and kidney tissues of albino rats. 50 albino rats were divided equally into five groups respectively orally fed with lead acetate and cadmium chloride at 25 mg/Kg body weight, and 5.0 mg/kg. Body weight. The blood of each animal was collected and biochemical assays were conducted. Data were processed with SPSS 15.0. The results showed a significant increase in lead and cadmium residues in groups exposed to lead and cadmium. Not only that but also, the function of oxidative damage in Pb and Cd induced changes in the liver and kidney. Administration of thioctic acid as a treatment for these changes lead to significant improvement for these ratio. In conclusion, this study highlights a real problem of public health, in the light of thousands of patients receiving random therapy after exposure to heavy metals