This study aims to prepare two different superplasticizers particularly acetone formaldehyde sulfanilate (AFS) and acetone glyoxylic sulfanilate (AGS); also, their effect on physico-chemical and mechanical properties of oil well cement was studied. The chemical structures were confirmed by FTIR technique. The prepared compounds were evaluated as superplasticizers for cement pastes. The cement pastes were prepared by the addition of the prepared admixtures; AFS or AGS, to cement by the ratios of 0, 0.25, 0.50, 0.75, and l.00 as mass % of cement. The water of consistency, combined water content, the rate of hydration and compressive strength of the hardened pastes were determined at different time intervals. The phase composition and microstructure of the hardened pastes were studied by DSC and XRD techniques. The results revealed that as the admixture dose rate increases the demand water for consistency of the cement paste decreases. Also, as the admixture addition rate increases the chemically combined water content decreases, so the rate of hydration decreases; meanwhile compressive strength increases due to the low initial porosity of the sample.