The current study was conducted to determine the effect of cutaneous leishmaniasis on some haematological and immunological parameters. 80 samples are examined from patients in areas of north Baghdad - Iraq. Patients are (40 males and 40 females), and 40 samples from healthy persons (20 males and 20 females) as a control group from December 2016 to August 2017. Results of the haematological parameters showed a significant increase in the number of red blood cells (RBC) of infected females compared to non-infected, while there is no significant difference between infected and non-infected males. Significant decrease in packed cell volume (PCV) is found in infected males, while there is no difference in infected females compared to non- infected. There is also significant decrease in haemoglobin (Hb) concentration in the infected females and males compared when compare with the control group. There was a significant decrease in the white blood cell count (WBC) in infected females, while there is no difference in males. There is a significant increase in lymphocyte and monocyte in both males and females compared to control, while there is a significant increase in neutrophil for males, and there is no difference in females. The results of immunological parameters showed that there were 62 positive for IgG cases and 18 for positive IgM cases, thus indicating 62 positive cases and 18 negative anti-nucleic antibody (ANA) cases. There was no significant difference according to the different ages, for both sexes with the result obtained for ANA. Regarding interleukin (IL-10) level there is significant difference between the ages in female and males' groups, there is no significant difference between the sexes and the type of infections. There is a significant difference in concentration of interleukin depending on the duration of the infection