This effort deals with uranium removal from liquid waste using Natural Nile Mud (NNM). Accordingly, cost effective and simple approach to remove uranium from liquid waste by NNM was reported. The effects of shaking time, pH, the initial uranium concentration, adsorbent temperature, adsorbent amount (dose) and effect of foreign ion (iron) on the adsorption of uranium ions from liquid waste were examined. According to the results, the optimum conditions for maximum adsorption efficiency of the NNM for uranium from the solution were obtained fitted with the Langmuir and the maximum adsorption capacity was about 61 mg/g NNM.