A descriptive study, aiming at determining factors affecting assertiveness among head nurses and their staff nurses, was conducted at Suez CanalUniversityHospital. The sample was composed of 31 head nurses and 162 staff nurses. Assertiveness Assessment Scale, Job Satisfaction Questionnaire, and Leadership Profile Scale were used to collect the data. The results of the study revealed that, majority of head and staff nurses were assertive, 41.9% of head nurses were satisfied with their job while 37.0% of staff nurses were satisfied, majority of head nurses (83.9%) were adopting the mixed style of leadership, a positive statistically significant correlation between head nurses leadership style and staff nurses' scores of assertiveness was observed. Since job satisfaction and leadership style had a positive influence on nurses' assertiveness, the study recommended that efforts should be done to increase nurses' job satisfaction, by increasing their salary, complete orientation for hospital policy and recognize their efforts and use different methods of to motivate them. Training program should be developed for head nurses to improve their leadership skills with concentration on suitable leadership style.