The use of music in healing is as old as the origin of human civilizations. This study aims to assess (1) reaction of autistics to music therapy (2) the effect of music therapy on autistics verbal communication, social traits, sensational and neurological perception and physical symptomatology. The study was conducted at El  Basma center for children with special needs in Shebin El Kom at Menoufya. All available autistic children (30) were selected. Two tools were utilized for data collection. One tool was developed by researchers and the other tool was developed by Mohammed A (2005). The results showed that autistic children had high interaction with music . Also, music therapy had a positive influence on reducing some associated unaccepted autistic problems related to verbal, communication, cognitive  and their physical health status. Therefore, it was concluded that music therapy could reduce unwanted autistic traits and the sufferings of autistic children. Also, it is recommended that nurses caring for autistics must have talents in music and the will to compose songs for them.