Attention Deficit Hyperactivity Disorders (ADHD) is associated with impairment in a number of important domains, including the parent-child relationship. Parents of children with ADHD experience considerable stress, lower parenting self-esteem, and a higher prevalence of depression, marital problems, and divorce. Therefore, this study was conducted to assess psychosocial problems of parents of children with ADHD, and to assess the strategies these parents apply to adjust with these problems .A descriptive exploratory design was utilized in this study. The study conducted at the health insurance outpatient psychiatric clinic, in psychiatric center for children in El-Khalafawi at Cairo.  A sample of convenience of 50 parents and their children coming to the above mentioned sitting were recruited for this study.  Four tools were used for data collection; child Medical and Developmental Data Sheet, Psychosocial problems of parents Scale, Parental coping strategy Inventory (PCSI) and Attention deficit hyperactivity disorder scale (ADHD).  Finding of this study indicated that, parents have high level of uncertainty about the cause of the syndrome. To conclude, parents of children with ADHD are frequently confronted with various kinds of psychosocial problems. These problems include fear, depression, anxiety and social isolation. The study recommended that, counseling clinics for parents of ADHD children are needed to ensure an effective and sensitive response to the needs of ADHD children and their families.