Background: Nursing management of newborn with hyperbilirubinemia requires a comprehensive approach. Jaundice is one of the most common conditions needing medical attention in neonates. Approximately 60% of term and 80% of preterm neonates develop jaundice in the first week of life. Aim of the study was to establish basic standards for nursing management of neonates with hyperbilirubinemia. Subject & Methods: Research Design: A descriptive qualitative design. Setting: The neonatal intensive care units of the University Children's Hospital at Zagazig University Hospitals. Subjects: Two groups of subjects were included: a expert group and nursing group. The expert group consisted of 37 experts including nurses' supervisors, head nurses and assistance of head nurses and they were 12 members, 19 medicine faculty members, and 6 nursing faculty members. The nursing group consisted of 33 nurses. Tools of data collections: Four tools were used to collect data: structure interview sheet,Knowledge assessment sheet ,Observational checklist and Resources checklist:. Results: The study revealed that there was general agreement from the expert group regarding the broad basic competencies and its underlined supported standards. Based on that result, standard of nursing care of neonates with hyperbilirubinemia was established. The proposed standards had acceptable face and content validity though agreement of a group of jury. Conclusion: It can be concluded that the study achieved its goal of establishing standard of nursing care for neonates with hyperbilirubinemia. The established standard includes structure, process, and outcome standards with emphasize on "process standard". Recommendations: It is recommended to apply the developed nursing standards in the study setting and also in similar settings in other hospitals.