Chronic obstructive pulmonary disease (COPD) is a disease state characterized by progressive and irreversible airflow obstruction. The COPD is an important public health problem in both developed and developing countries with a high prevalence among persons with low socioeconomic status and in countries where cigarette smoking is still very common. The COPD is a source of significant disability in work life, family role, and functions of daily living, thereby health-related quality of life (HRQoL) decreases. The aims of this study were to assess patients' knowledge about COPD and evaluate their HRQoL, which might affect their management. adescriptive design was used to achieve the aim of the study. The study subjects composed of 100 patients, all of them were drawn from the Out Patient Chest Clinic and Department of Chest Diseases at Zagazig University Hospitals. Data was collected by using a questionnaire sheet which designed by the investigator after reviewing related literature. Results of the study revealed that the total correct patients' knowledge regarding their disease was low (14%), the COPD has an impact on the subjects health, function and performing their activities of daily living. The majority (82%) of the study subjects were suffering from psychological disturbance. Thus a respiratory rehabilitation program for these patients is recommended to improve their quality of life and provide them with adequate information about COPD and how they cope with there chronic disease and disability caused by it