A major burn is accompanied by an overwhelming insult to the patient, both physically and psychologically.  Burn patients require specialized care, and need to be involved in developing a daily plan of care. This study aimed to design and implement self-care strategies for burn patients based on needs assessment, and to evaluate the effect of its application on burn patients'' physical and psychological aspects. This quasi-experimental pre-post and follow up assessment study was done at the burn unit at El-DemerdashHospital. The sample included 60 patients with second degree burn injury, able to engage and perform the self-care activities, selected through systematic random sampling from the patients admitted from October 2003 to April 2004.  Three different tools were used for data collection, a patient needs assessment sheet, a knowledge assessment form, and an observation checklist to assess patient''s performance of self-care activities.  The content, sessions, teaching methods and media were prepared, and a booklet was designed to include the self-care strategies, and used to teach patients. Totally, 15.0% of the patients had physical needs, 20.0% had depression and 6.7% had anxiety.  The highest need was for non-medical support (36.7%).  Patients’ knowledge and performance related to burns has shown statistically significant improvements in almost all its aspects throughout the intervention phases, p