Background: Loneliness has shown to be particularly prevalent in college students. In fact; it was one of the most common complaints of students reporting to health and counseling centers. Aim of the study: was to determine relationship between loneliness and self-esteem among students at Faculty of Nursing, Zagazig University. Subjects & Methods: Research design: A descriptive design was used. Setting: the present study was conducted at the Faculty of Nursing, Zagazig University. Subjects: Three hundred and twelve nursing students were enrolled in the present study. Tools of data collection: Socio-demographic data sheet, Russell Loneliness Scale and Rosenberg scale of Self-esteem. Results: the present study showed that more than half of the studied sample had Loneliness feelings and the majority of the studied sample had high level of self-esteem .There was negative correlation between loneliness and self-esteem. Conclusion: Based on the findings of the present study, concluded that self-esteem had positive impact in lowering level of loneliness. Recommendations: The study recommended that, establishing psychosocial counseling center or psychiatric clinic at Faculty of Nursing to assist students to handle issues that constitute a source of stress in their life