Essential Hypertension is a common chronic disease and a serious health care problem in both developed and developing countries. Compliance toward different therapeutic regimen is a key factor in controlling blood pressure. Aim of study was to evaluate effect of an educational program on compliance of patients with essential hypertension toward therapeutic regimen. Subjects and methods: Research design: A quasi experimental research design was utilized in this study. Setting: This research was carried out in the outpatient clinic at Specialized Medical Hospital, Mansoura University. Subjects: A purposive sample of 120 adult patients with essential hypertension from both sex, aged 30-60 years and on antihypertensive treatment were recruited for the current study. Tool of data collection: Data collected through; assessment of patients' socio-demographic characteristics, Hypertension Knowledge Level Scale, and compliance through Hill Bone Scale. Results; Improved patients' compliance toward therapeutic regimen post implementing program with highly statistically significant difference with P ≤ 0.001, as well; the findings showed that a highly positive correlation between patients' knowledge and their compliance toward therapeutic regimen. Conclusion: The educational program was effective in the management of hypertensive patients through improving their compliance toward therapeutic regimen. Recommendations It is recommended to apply this program as a routine in the study setting and similar ones. In addition to design a training program for outpatient nurses about hypertension and its management.