Background: A high quality of work life (QWL) is essential for all organizations to continue to attract and retain employees. Quality of work life is a comprehensive program which is designated to increase employee satisfaction. Aim of the study: to explore the relationship between quality of work life (QWL) and organizational citizenship behavior (OCB) among nurses. Subjects & Methods: Research design: Descriptive, correlational design was utilized. Setting: This study was conducted at El-Mansoura health insurance hospital. Subjects: include convenience sample of nurses (N=250). Tools of data collection: 1st tool: Quality of work life (QWL) questionnaire and 2nd tool: Organizational citizenship behavior questionnaire. Results: The majority of the study participants had low quality of work life. On the other hand nearly to half of them had a low level of organizational citizenship behavior, And there was a highly statistical significance between total quality of work life and organizational citizenship behavior Conclusion: There was a positive correlation between total Quality of work life and Organizational citizenship behavior and there was a highly statistically significant relation between total level of the quality of work life and organizational citizenship behavior of the studied participants. Recommendations: Creating healthy work conditions for nurses and provide freedom to act according to their expectation as a professional and regular meeting must be conducted periodically between supervisors and their staff nurses to discuss and solve their problems.