This paper presents a novel design of an FPGA-based, reprogrammable digital clock generator that produces a group of clock signals with variable duty cycles. The realized chip provides up to fourty eight, independent, crystal-controlled, variable-duty-cycle clock outputs; each having a duty-cycle that can be varied from 0.4 % to 99.6 % in 250 steps. The proposed design can be used in a variety of applications. One of the main applications is the adjustment of the synaptic weights of an artificial neural network (ANN). The designed unit can also be used as the basis of a highly flexible pulse generator or a complex waveform generator.