ABSTRACT This paper presents a noval design method of prilling tower which was integrate from sub-models dealing with the importance basic concepts of the prilling process. This design methodology allowes an approximation for certain sub -models while retining some level of detail for other sub-models depending on which sub-model needs to contract and which to expend .The overall model was supported by CFD Stimulation cod (Fluent 6.3) which was a promising tool in analyzing and designing of the tower. In relating to this methodology, a number of important criteria were suggested against which the adequacy of the design results was tested. The prilling of highly concentrated ammonium nitrate solution was considered as case study. Producing an auniform size of prills was acocomplished by using considered as a head spray system where creating a quiescent zone at the spray system had a significant effect of decreasing the second disintegration of the droplets. The measured size of produced prills was greater than the predicated due to the presence of an ammonium bubble at the center of the prills, therefore, spray ability and the physical- chemical properties of the material must be carefully considered before preceding the tower design.