34670

Comparison between Different Techniques in Purification of 18O Enriched Water after Cyclotron Irradiation

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Last updated: 04 Jan 2025

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Abstract

Abstract
In the synthesis of 18F-FDG by nucleophilic substitution method, 18O-H2O is usually used as target water. The high cost of virgin 18O-H2O enriched water pointed to recycle process after the first irradiation for the production of radiopharmaceuticals. The irradiated 18O-H2O was contaminated by both organic substances (ethanol, acetonitrile, etc.) and inorganic ions (Cd2+, Na+, K+, Cl-, etc). In our study different techniques (ozonolysis, UV, distillation and resin) were used to minimize the concentration of both organic substances and inorganic ions and evaluate the effectiveness of resin as method for the purification. The concentration of the TOC was decreased from 705 (mg/L) for the irradiated18O water to 12.36 (mg/L) and 4.8 (mg/L) by using UV and ozonolysis respectively. While the concentration of metal ions decreased and the conductivity decreased from 487 μ Si/cm for the irradiated 18O water to 51.9 μ Si/cm when regenerated resin was used and to 20.8 μ Si/cm by distillation.

DOI

10.21608/iccee.2018.34670

Authors

First Name

M.

Last Name

Masoud

MiddleName

S.

Affiliation

Chemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt.

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Orcid

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First Name

A.

Last Name

El-Kholany

MiddleName

S.

Affiliation

Medical Laboratory Technology Department, Faculty of Allied Medical Sciences, Pharos University, Alexandria, Egypt.

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Orcid

-

First Name

M.

Last Name

El- Shahat

MiddleName

F.

Affiliation

Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.

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Volume

9

Article Issue

9th International Conference on Chemical & Environmental Engineering

Related Issue

5728

Issue Date

2018-04-01

Receive Date

2019-06-13

Publish Date

2018-04-01

Page Start

295

Page End

306

Print ISSN

2636-4336

Online ISSN

2636-4344

Link

https://iccee.journals.ekb.eg/article_34670.html

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https://iccee.journals.ekb.eg/service?article_code=34670

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16

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Original Article

Type Code

832

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Journal

Publication Title

The International Conference on Chemical and Environmental Engineering

Publication Link

https://iccee.journals.ekb.eg/

MainTitle

Comparison between Different Techniques in Purification of 18O Enriched Water after Cyclotron Irradiation

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Article

Created At

22 Jan 2023