This study investigated the effects of dietary orange peels (OP), pommengrate peels (PP) and Banana peels (BP) wasting from juice industry on growth performance, feed utilization and immunity in fish. T1, T2 and T3 had 3% of Orange, Pommengrate and Banana peels respectively, T4 had mixture of 1.5% (OP) and 1.5% (PP), T5 had mixture of 1.5% (OP) and 1.5% (BP), T6 had mixture of 1.5% (OP) and 1.5% (PP), T7 mixture of 1% of each of them and T8 fish fed diet free from any additives (control group). T7 showed significantly high level of weight gain (63.07±1.79 a) and feed efficacy (107.19±2.06a) followed by T1, T4, T5 FER increase respectively 83.86±1.65 c, 80.76±0.95 cd and 90.44±3.98 b than T8 control group (76.16±1.07 d). Similarly, highest values of total proteins, albumin, and globulin were significantly observed in T7 and T1 groups. Likewise, (T7) had a significant increase in lysozyme activity in serum 3.51±0.03a followed by T4 (3.07±0.07b), T1 (3.01±0.07b).T5 (2.73±0.03c) more than control group T8 (1.28±0.03 f). All treated groups had higher level of protection than control group as Treatment 7 showed highest survival rate 90% than control group (60%). Similarly, survival rate in O. niloticus challenged with Saprolegnia spp. were 100% in all groups except treatment 4 had a lower percent 90% more than control group (50%). So the present investigation recommended that use of mixture of 1% (OP), 1% (PP) and 1% (BP) to improve the growth, immunity and tolerance of Nile tilapia to bacterial and fungal infection.