The main objective of this study was the use of (Artimizia) extract as immunostimulant effect, growth promoters and fish resistance to Aeromonas hydrophila infection; in Nile tilapia, Oreochromis nilocticus fingerlings.  Four monosex fish (12 ± 2 gram) groups fed commercial diets (30% crude protein) and isocaloric (4.4 kcal/gm) contained 0.0 (control) and 0.5, 1, and 1.5% of Artimizia extract. All diets are isonitrogenous. The result showed that Diet containing 0.5% Artimizia extract significantly (p< 0.05) gave the better growth  performance as reflected in weight gain %, Specific Growth Rate (SGR), Feed Conversion Ratio (FCR), Feed Efficiency Ratio (FER), Protein Efficiency Ratio (PER), Apparent Protein Utilization (APU) and Energy Utilization (EU). Also the survival rate was enhanced. Artimizia extract supplemented diet had no effect on body composition of O. nilotiticus. (Artimizia) extract supplement diet improved fish health, which improved Hemoglobin (Hb), Red Blood Cells (RBCs), hematocrit (PCV), total protein, albumin and globulin while showed a decrease in creatinine, urea, Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and glucose in all treatment groups. Artimizia extract supplement diet had Positive effect on Hb, RBCS, PCV, total Protein, albumin, globulin, creatinin, glucose, urea, AST and ALT.