The  effect of carob pods (Ceratonia siliqua)  and fig fruits (ficus carica) ether extracts 600 mg/kg in  the diet   against  sublethal doses of Pb (1/2  and 1/4 LC50)  on   aspartate amino transferase (AST) , alanine amino transferase (ALT) , urea  , creatinine  and   accumulation of lead in muscle and visceral organs in  (Oreochromis niloticus) was investigated .The half  lethal  concentration (LC50) for 96 hr was 155 mg/l . Results showed that   aspartate amino transferase (AST) , alanine amino transferase (ALT) , urea  , creatinine  and   accumulation of lead in muscle and visceral organs was increased after exposed to 1/2 LC50 and 1/4 LC50 of  Pb for 30 ,60 and 90 days. On the other hand  O. niloticus exposed to 1/2 LC50 and 1/4 LC50 of  Pb and fed with diet contain 600 mg of carob  extract /kg for 90 days showed  no significant changes in  creatinine ,   accumulation of  lead in muscle and visceral . Also  the fish exposed to 1/2 LC50 and 1/4 LC50 of  Pb  and fed with diet contain 600 mg of fig  extract /kg for 90 days revealed  no significant changes  in  AST , ALT , urea , creatinine ,   accumulation of lead  in muscle and visceral organs.It could be concluded that both carob and fig ether extracts had ameliorative effect against lead acetate toxicity in Oreochromis niloticus.