The present study was conducted to evaluate the effect of Moringa oleifera seeds extracts in two different solvents ethanol and petroleum ether on the reproductive performance and physiological state of Nile Tilapia. Fish were stocked in 15 concrete ponds, grouped into 5 treatments in triplicates for each treatment. The first treatment T1 (control without any moringa extract), the second T2 and the third T3 (containing respectively 0.5 g and 1 g of moringa seed ethanol extract (MSEE)/kg diet), the fourth T4 and the fifth  T5 (containing respectively 0.5 g and 1 g of moringa seed petroleum ether extract (MSPEE)/kg diet). The experiment extended to 70 days. The results showed that the highest numbers of fry production and ovaries weights were obtained with T4 and T5.  The best treatment for blood hematological parameters is T4 and the highest level of testosterone and esteradiol hormones were observed in all moringa treatments. Thus it was concluded that 0.5 g of Moringa seed petroleum ether extract/kg was useful for the improvement of the reproductive performance and physiological blood characteristics of brooding stock Nile tilapia fish.