the purpose of the present study was to compare protein catabolism indicator (blood urea nitrogen [BUN]), muscle damage indicators ( lactate dehydrogenase (LDH) and myoglobin (Mb) ) and inflammation indicator (interleukin (IL6) ) after a single plyometric exercise (PE) session performed in water and on grass . Fifteen healthy and physically active male third year students at the faculty of physical education for boys, with a mean age of 20.62  ±.59 years, a height of173.8 ± 4.95 cm, and a body mass of 72.67 ± 8.27 kg participated in this study . the result showed that there are statistically significant differences between aquatic and Grass group measurements in all variables of the research except LDH . The present study can recommend that coaches and strength & conditioning professionals use Aquatic Plyometric or safe surfaces like a firm surface for plyometric training to decrease muscle damage.