271484

Effect of Low Dose Aspirin on Luteal Phase Uterine Artery Doppler Indices in Women with Recurrent Pregnancy Loss

Article

Last updated: 04 Jan 2025

Subjects

-

Tags

Gynecology and Obstetrics

Abstract

Background: The obstetrical difficulties associated with repeated miscarriages persist. It's associated with poor uterine blood flow, and vasodilators seem to stop miscarriages from happening again.  
Aim of the work: During the luteal phase, Doppler indices of the uterine artery were measured to see whether low-dose aspirin had any effect on recurrent miscarriage.
Patients and methods: Patients experiencing recurrent pregnancy loss [RPL] were randomly assigned to one of two treatment groups in a randomized controlled trial [RCT]; Group A [Case Group]: subjects were those who had a history of two or more recurrent miscarriages and who were administered a modest dosage of Aspirin Group B [Control Group]: Subjects with a history of two or more consecutive miscarriages were not administered Aspirin. Studied Doppler indices included Systolic-to-diastolic ratios [S/D], resistance index [RI] and pulsatility indices [PI]  
Results: RI, PI, and S/D were significantly lower among group A group compared to group B group after treatment with aspirin in group A. Individuals who had had one or two prior miscarriages had the lowest uterine index values, although this difference was not statistically significant.
Conclusion: Uterine blood flow was reduced during the luteal phase in those who had had repeated miscarriages. Aspirin, even at modest doses, increased uterine blood flow, and this effect was reversible, suggesting its potential therapeutic use.

DOI

10.21608/ijma.2022.165107.1519

Keywords

aspirin, Recurrent pregnancy loss, uterine artery blood flow

Authors

First Name

Mohamed

Last Name

Mansour

MiddleName

Yousry

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

Email

doctormohamed.2017@gmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Gebriel

MiddleName

Mohamed

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

Email

budo20052001@yahoo.com

City

Cairo

Orcid

-

First Name

Muhamed

Last Name

Abdelmoaty

MiddleName

Ahmed

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

Email

muhamedahmed.216@azhar.edu.eg

City

New-Damietta

Orcid

-

Volume

4

Article Issue

9

Related Issue

38821

Issue Date

2022-09-01

Receive Date

2022-09-25

Publish Date

2022-09-01

Page Start

2,657

Page End

2,663

Print ISSN

2636-4174

Online ISSN

2682-3780

Link

https://ijma.journals.ekb.eg/article_271484.html

Detail API

https://ijma.journals.ekb.eg/service?article_code=271484

Order

6

Type

Original Article

Type Code

816

Publication Type

Journal

Publication Title

International Journal of Medical Arts

Publication Link

https://ijma.journals.ekb.eg/

MainTitle

Effect of Low Dose Aspirin on Luteal Phase Uterine Artery Doppler Indices in Women with Recurrent Pregnancy Loss

Details

Type

Article

Created At

22 Jan 2023