Background: The Status Epilepticus Severity Score (STESS) has become frequently utilized in recent years to predict the prognosis of SE patients (status epilepticus).

Objective: The study's purpose was to find determinants of SE severity and short-term outcomes in SE patients admitted to the hospitals of Al-Azhar University.

Patients and methods: At the hospitals of Al-Azhar University in Cairo, Egypt, A prospective observational study of 43 consecutive SE patients admitted and treated over six months was done. Demographics and clinical data from established SE patients were gathered, and their association to SE duration and short-term outcomes was examined.

Results: The STESS findings demonstrated a statistically significant connection between the failure to respond to therapy after one hour (P-value = 0.0001). There was a tendency (P-value = 0.7508) toward greater fatality, the necessity for coma induction (P-value = 0.1799), and a bad outcome (P-value = 0.0636), with a higher STESS score. A STESS score of < 3 has NPV of 96.67 % for fatality, 76.67 % for the necessity for coma induction, and 53.85 % for bad outcomes.

Conclusion: The outcome of status epilepticus can be consistently predicted using STESS. Additional research on STESS-based treatment techniques could aid in the development of more effective SE treatment regimens.