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221970

Curcumin and Silymarin Amelioration of the Bisphenol-A induced Hepatotoxic Effects in Male Albino Rats: A structural, Biochemical and Molecular Experimental Study

Article

Last updated: 04 Jan 2025

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Tags

Basic Sciences

Abstract

Background: Bisphenol A [BPA] is widely used in industrial processes. It persists in environment and exerts a harmful action on human health, through endocrine-disruption. Many natural compounds are suggested to have a preventive effect on BPA-induced human health hazards.
Aim of the work: This study aimed to evaluate the effect of Silymarin/Curcumin in ameliorating the hepatotoxic effect induced in albino rats following oral administration of BPA.
Patients and Methods: Fourty adult male albino rats were included and randomly categorized into four equal groups. The control group and BPA-exposed [50 mg/kg] group. Groups 3 and 4 for rats received oral BPA [50 mg/kg] plus [100 mg/ kg] of curcumin or silymarin. Serum liver enzymes, pro-inflammatory cytokines [TNF-α & IL-1,6,8] and the oxidant/antioxidant profile were assessed in the serum. SOD, GPX and CAT levels, MDA and H2O2 were assessed. Histopathological changes of the liver, immunohistochemical detection of caspase 3 and area density of collagen fibres were also assessed.
Results: Bisphenol-A administration for 30 days was associated with a significant increase in the number of pro-inflammatory markers as interleukin 1,6,8 and tumor necrosis factor‑α [TNF-α]. It also, stimulates oxidative stress with structural changes, apoptosis and fibrosis in hepatic cells. Treatment with curcumin or silymarin for 30 days lead to a reduction of pro‑inflammatory mediators and significant amelioration of structural changes.
Conclusion: Silymarin/Curcumin had an ameliorative of harmful effects of BPA on the liver cells through potent anti-inflammatory, antiapoptotic and antioxidant effects. 

DOI

10.21608/ijma.2022.221970

Keywords

bisphenol A, Liver, Oxidative stress, Hepatoprotective, Silymarin, Curcumin

Authors

First Name

Ibrahim Mahrous Ibrahim

Last Name

Amr

MiddleName

-

Affiliation

Department of Histology, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

ibrahimmahrousamr@yahoo.com

City

Zefta, Gharbia

Orcid

-

First Name

Osama Mohammed

Last Name

Abd El Hay

MiddleName

Mohammed

Affiliation

Department of Physiology, Faculty of Medicine, Al-Azhar University, Egypt

Email

osama.m.m.abdelhay@gmail.com

City

-

Orcid

Osama abdelhay

First Name

Mohamed Gaber Mohamed

Last Name

Hasan

MiddleName

-

Affiliation

Department of Physiology, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

m_gaber55@yahoo.com

City

Sharqia

Orcid

-

First Name

Mahmoud

Last Name

Diab

MiddleName

-

Affiliation

Department of Anatomy and Embryology, Faculty of Medicine, Al-Azhar University, Egypt

Email

drmahmoud99@hotmail.com

City

Cairo

Orcid

-

First Name

Amal H.

Last Name

Ibrahim

MiddleName

-

Affiliation

Department of Internal Medicine, Faculty of Medicine for Girls, Al-Azhar University, Egypt

Email

mkellany@yahoo.com

City

New Damietta City, Damietta, Egypt

Orcid

-

First Name

Ahmed Mohammed

Last Name

Taha

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Medicine, Helwan University, Egypt

Email

ahmed999taha@yahoo.com

City

Cairo

Orcid

-

First Name

Samir Atef Farid

Last Name

Elmetwally

MiddleName

-

Affiliation

Department of Forensic Medicine and Clinical Toxicology, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

samiratef498@gmail.com

City

Damietta, Egypt

Orcid

-

First Name

Moaaz Moustafa Yousef

Last Name

Awad

MiddleName

-

Affiliation

Department of Anatomy and Embryology, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

moaaz19810@gmail.com

City

Damietta, Egypt

Orcid

-

Volume

4

Article Issue

2

Related Issue

31847

Issue Date

2022-02-01

Receive Date

2021-11-30

Publish Date

2022-02-01

Page Start

2,141

Page End

2,148

Print ISSN

2636-4174

Online ISSN

2682-3780

Article File

IJMA_Volume 4_Issue 2_Pages 2141-2148.pdf

PDF . 2.8MB

Link

https://ijma.journals.ekb.eg/article_221970.html

Detail API

https://ijma.journals.ekb.eg/service?article_code=221970

Order

9

Type

Original Article

Type Code

816

Publication Type

Journal

Publication Title

International Journal of Medical Arts

Publication Link

https://ijma.journals.ekb.eg/

MainTitle

Curcumin and Silymarin Amelioration of the Bisphenol-A induced Hepatotoxic Effects in Male Albino Rats: A structural, Biochemical and Molecular Experimental Study

Details

Type

Article

Created At

22 Jan 2023