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187697

Seroprotection Status of Hepatitis B Vaccine in Children with Type 1 Diabetes Mellitus

Article

Last updated: 04 Jan 2025

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Subjects

-

Tags

Pediatrics

Abstract

Background:"Type 1 diabetes mellitus [T1DM]" is the most common endocrine disease in the Pediatric population. It has been suggested that T1DM had inadequate immunological response to vaccines, including hepatitis B virus [HBV] vaccine.
Aim of the Work:To evaluate the immunological status against HBV vaccine among children with T1DM, and assess various possible risk factors for immunity failure.
Patients and Methods:A comparative cross-sectional study included 60 children [4-10 years] with T1DM [case group], and 60 healthy age- and sex-matched children [control group]. All included children had completed obligatory HBV vaccine. The evaluation of the immunological response was assessed through analysis of antibodies against HBV surface [HBsAB]. Seroprotection status to HBV vaccine was identified as plasma HBsAB of ≥ 10 mIU/ml.
Results:The mean duration of T1DM was 2.03 ± 1.73 years. The frequency of immunity failure to HBV vaccine [non-responders; HBsAB < 10 mIU/ml] was 51.7% among the case group, and 28.3% among the control group [P = 0.009]. Risk factors for immunity failure, as evaluated by regression analysis, were older age [P=0.002], and longer duration of T1DM [P=0.023].
Conclusion: Children with T1DM have a reduced level of HBV vaccine seroprotection when compared to the control group. Patients with older age and longer duration of T1DM showed a trend toward non-responding HbsAB titer. Long-term follow-up of responders is recommended to retest the level of immune response. 

DOI

10.21608/ijma.2021.81707.1331

Keywords

seroprotection, hepatitis B, vaccine, Type-1 Diabetes Mellitus

Authors

First Name

Dina

Last Name

Elsharkawy

MiddleName

Mohamed Ahmed

Affiliation

Department of Pediatrics, Sporting Students' Hospital, Ministry of Health, Egypt

Email

dina.pediatrics@domazhermedicine.edu.eg

City

-

Orcid

-

First Name

Hany Abd Elhady

Last Name

El-khaleegy

MiddleName

-

Affiliation

Department of Pediatrics, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

hanykhaleegy@yahoo.com

City

-

Orcid

-

First Name

Saad

Last Name

Mohamed

MiddleName

Ahmed

Affiliation

Department of Pediatrics, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

saad_dawody@yahoo.com

City

-

Orcid

-

First Name

Gamal

Last Name

Mohamed

MiddleName

Ahmed

Affiliation

Department of Clinical Pathology, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

gemy1412@gmail.com

City

-

Orcid

-

Volume

3

Article Issue

3

Related Issue

27050

Issue Date

2021-07-01

Receive Date

2021-06-21

Publish Date

2021-07-01

Page Start

1,748

Page End

1,753

Print ISSN

2636-4174

Online ISSN

2682-3780

Article File

IJMA_Volume 3_Issue 3_Pages 1748-1753.pdf

PDF . 1.7MB

Link

https://ijma.journals.ekb.eg/article_187697.html

Detail API

https://ijma.journals.ekb.eg/service?article_code=187697

Order

187,697

Type

Original Article

Type Code

816

Publication Type

Journal

Publication Title

International Journal of Medical Arts

Publication Link

https://ijma.journals.ekb.eg/

MainTitle

Seroprotection Status of Hepatitis B Vaccine in Children with Type 1 Diabetes Mellitus

Details

Type

Article

Created At

22 Jan 2023