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174076

Oral Isotretinoin in the Treatment of Recalcitrant Molluscum Contagiosum in Children

Article

Last updated: 04 Jan 2025

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Subjects

-

Tags

Dermatology

Abstract

Background:Recalcitrant molluscum contagiosum in children has been treated with many destructive procedures with a high recurrence rate, alternative treatments would be desirable in pediatric patients. Oral isotretinoin has been used to treat viral warts successfully in children.
Aim of the work: Our aim in this study wasto investigate the influence of oral isotretinoin in MC patients.
 Methods: Twenty children less than 18 years, with recalcitrant molluscum contagiosum were enrolled in this study, the treatment protocol was oral isotretinoin [0.5 mg/kg] daily until complete clearance [maximum duration 3 months]. Patients were evaluated clinically and photographically every two weeks to assess the response to treatment and to report side effects of therapy. Patients with complete response were followed up monthly for three months to record the recurrence rate. Lipid profile [Triglycerides, cholesterol, LDL and HDL] and liver function tests [SGOT and SGPT] were performed before treatment and every 4 weeks during the treatment period.
Results:Mean age of participants was 12.90 ± 2.64 years, 80% of them were more than 10 years old, [65%] were male, and the mean weight of studied cases was 49.10 ± 15.33 kg. The face was most common affected site in most cases [45%]. The mean lesion size was 2.63 ± 1.11 mm, and mean number of molluscum lesions of 23.55 ± 12.85.  As regarding to recurrence rate, 93.8% of cases who had complete response were still free at the end of 3 months follow up and only 6.3% had recurrence. Reported side effects were dry lips in all participants, 55% had a dry skin and 30% had a dry nose.
Conclusion: Oral isotretinoin therapy improves recalcitrant MC lesions in children, which maycontribute to its therapeutic efficacy.  

DOI

10.21608/ijma.2021.71160.1293

Keywords

Isotretinoin, molluscum contagiosum, children

Authors

First Name

Rahma

Last Name

Ramdan

MiddleName

-

Affiliation

Department of Dermatology, Venereology and Andrology, Dermatology and Leprosy Hospital in Damietta, Ministry of Health, Egypt

Email

rahma_ramdan2020@yahoo.com

City

-

Orcid

-

First Name

Hany

Last Name

Abou Alwafa

MiddleName

-

Affiliation

Department of Dermatology, Venereology and Andrology, Al-Azhar Faculty of Medicine, Damietta, Egypt

Email

dr_hanyos138@yahoo.com

City

-

Orcid

-

First Name

Emad Eldin

Last Name

Elgamal

MiddleName

-

Affiliation

Department of Dermatology, Venereology and Andrology, Al-Azhar Faculty of Medicine, Damietta, Egypt

Email

elgamal55@yahoo.co.uk

City

-

Orcid

-

Volume

3

Article Issue

3

Related Issue

27050

Issue Date

2021-07-01

Receive Date

2021-04-05

Publish Date

2021-07-01

Page Start

1,598

Page End

1,601

Print ISSN

2636-4174

Online ISSN

2682-3780

Article File

IJMA_Volume 3_Issue 3_Pages 1598-1601.pdf

PDF . 1.4MB

Link

https://ijma.journals.ekb.eg/article_174076.html

Detail API

https://ijma.journals.ekb.eg/service?article_code=174076

Order

14

Type

Original Article

Type Code

816

Publication Type

Journal

Publication Title

International Journal of Medical Arts

Publication Link

https://ijma.journals.ekb.eg/

MainTitle

Oral Isotretinoin in the Treatment of Recalcitrant Molluscum Contagiosum in Children

Details

Type

Article

Created At

22 Jan 2023