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185126

Ketamine versus Dexmedetomidine in Local Wound Infiltration for Postoperative Pain Relief in Cesarean Section

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Gynecology and Obstetrics

Abstract

Background: Cesarean delivery is a frequently obstetric operation in Egypt with a recently reported over all cesarean section rate of 54% and it causes moderate to severe postoperative discomfort. Infiltration of the wound site is a method to improve postoperative analgesia.
The aim of the work: To compare the pain relief effects of ketamine versus dexmedetomidine combined to bupivacaine in local wound infiltration in patients underwent cesarean section and to estimate side effects of medications.
Patients and Methods: This randomized, controlled study including 90 women were subjected for elective cesarean delivery under general anesthesia and were divided at random into 3 equal groups to receive 40 ml bupivacaine (0.25%) + either 2 mg/kg ketamine in (group A), 2 μg/kg dexmedetomidine in (group B) or 2 ml saline in (group C) via local wound infiltration. The primary outcome was time of the first analgesia requested. The secondary outcomes were total dose of analgesia per 24 hours, Visual analogue scale, time of starting movement, breast-feeding, passing flatus or stool, start of eating and adverse effects of medications.
Results: A significant increase in time of the first analgesic request in group A (8.4 ±1.91) h. and group B (7.5±1.81) h. than group C (4.3±1.24) h. A significant decrease in pethidine consumption in group A (59 ± 28.93 mg) than group B (72 ± 23.1 mg) and group C (102 ±16 mg). The visual analogue scale (VAS) was significantly lower (p <0.001) in groups A and B than in group C. The time of start movement, breast-feeding, passing flatus and eating was decreased in groups A and B than in group C
Conclusions: Addition of ketamine or dexmedetomidine to local anesthetics wound infiltration increased time to the first analgesia request and decreased total analgesic consumption, but ketamine is superior.

DOI

10.21608/ijma.2021.185126

Keywords

Ketamine, Dexmedetomidine, local anesthesia, wound infiltration

Authors

First Name

Nourhan R.

Last Name

Biomy

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, El Hawamdyia General Hospital, Ministry of Health, Egypt

Email

nourhan_biomy@gmail.com

City

Cairo

Orcid

-

First Name

Asmaa

Last Name

Fathelbab

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University, Egypt

Email

asmaa_fathelbab@gmail.com

City

Cairo

Orcid

-

First Name

Amina

Last Name

Abdel-Fattah

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University, Egypt

Email

amona_update@yahoo.com

City

Cairo

Orcid

-

First Name

Abeer E.

Last Name

Farhat

MiddleName

-

Affiliation

Department of Anesthesia and Intensive Care, Faculty of Medicine, Al-Azhar University, Egypt

Email

abeer_farhat@gmail.com

City

Cairo

Orcid

-

Volume

3

Article Issue

3

Related Issue

27050

Issue Date

2021-07-01

Receive Date

2021-06-20

Publish Date

2021-07-01

Page Start

1,570

Page End

1,575

Print ISSN

2636-4174

Online ISSN

2682-3780

Article File

IJMA_Volume 3_Issue 3_Pages 1570-1575.pdf

PDF . 1.4MB

Link

https://ijma.journals.ekb.eg/article_185126.html

Detail API

https://ijma.journals.ekb.eg/service?article_code=185126

Order

10

Type

Original Article

Type Code

816

Publication Type

Journal

Publication Title

International Journal of Medical Arts

Publication Link

https://ijma.journals.ekb.eg/

MainTitle

Ketamine versus Dexmedetomidine in Local Wound Infiltration for Postoperative Pain Relief in Cesarean Section

Details

Type

Article

Created At

22 Jan 2023