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172330

Tyrosine Hydroxylase Expression is Associated with Bone Marrow Infiltration in Neuroblastoma Patients

Article

Last updated: 24 Dec 2024

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Subjects

-

Tags

Basic Sciences

Abstract

Background: Neuroblastoma is a complex heterogeneous disease. Bone marrow is the most commonly affected metastatic site.
The aim of the work: The current study aimed to assess the role of tyrosine hydroxylase in diagnosing bone marrow infiltration in neuroblastoma.
Methods: Tyrosine hydroxylase was assessed in the bone marrow aspirate of 104 pediatric neuroblastoma patients, compared to 25 matched normal controls by real time polymerase chain reaction. The data were correlated to the clinic-pathological features of the patients, response to treatment, bone marrow infiltration, disease free survival and overall survival.
Results: Tyrosine hydroxylase was expressed in 78/104 [75%] of the patients. Bone marrow infiltration was significantly higher in patients with high tyrosine hydroxylase expression compared to those with tyrosine hydroxylase low expression [median [range]: 193 [0-277750] versus 4 [0- 7849]; p=0.003]. Use of tyrosine hydroxylase for diagnosis of bone marrow involvement in neuroblastoma had a sensitivity of 55.2%, a specificity of 65.2%, and positive predictive value of 66.7% and negative predictive value of 53.6%.
Conclusions: Tyrosine hydroxylase may serve as a useful tool for diagnosis of bone marrow infiltration in neuroblastoma. Bone marrow infiltration is associated with poor disease free survival and overall survival.

DOI

10.21608/ijma.2021.70994.1292

Keywords

neuroblastoma, Tyrosine hydroxylase, Bone marrow

Authors

First Name

Samar

Last Name

El-Shazly

MiddleName

-

Affiliation

Department of Clinical Pathology, National Cancer Institute, Cairo University, Cairo 11976, Egypt

Email

samarsami.elshazly3@gmail.com

City

-

Orcid

-

First Name

Mona

Last Name

Abdellateif

MiddleName

-

Affiliation

Department of Medical Biochemistry, Molecular Biology, and Cancer Biology, National Cancer Institute, Cairo University, Cairo 11976, Egypt.

Email

mona.sayed@nci.cu.edu.eg

City

-

Orcid

-

First Name

Fadwa

Last Name

Said

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Cairo University, Egypt

Email

f2said@yahoo.com

City

-

Orcid

-

Volume

3

Article Issue

3

Related Issue

27050

Issue Date

2021-07-01

Receive Date

2021-04-04

Publish Date

2021-07-01

Page Start

1,562

Page End

1,569

Print ISSN

2636-4174

Online ISSN

2682-3780

Article File

IJMA_Volume 3_Issue 3_Pages 1562-1569.pdf

PDF . 2.0MB

Link

https://ijma.journals.ekb.eg/article_172330.html

Detail API

https://ijma.journals.ekb.eg/service?article_code=172330

Order

9

Type

Original Article

Type Code

816

Publication Type

Journal

Publication Title

International Journal of Medical Arts

Publication Link

https://ijma.journals.ekb.eg/

MainTitle

Tyrosine Hydroxylase Expression is Associated with Bone Marrow Infiltration in Neuroblastoma Patients

Details

Type

Article

Created At

22 Jan 2023