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169689

Comparative Study between Topical Latanoprost versus Topical 5- Fluorouracil after Dermabrasion for Treatment of Non-Segmental Stable Vitiligo

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Dermatology

Abstract

Background: Latanoprost [LT], a prostaglandin F2-alpha [PGF2α] analogue used in the treatment of glaucoma. It induces skin pigmentation in guinea pigs. The rationale of trying 5-fluorouracil [5‐FU] in vitiligo treatment may come from the first report of hyperpigmentation induced by 5‐FU as a side effect in the skin tumors and psoriasis treatment
The Aim of the work: Comparison between the efficacy of topical latanoprost versus topical 5-fluorouracil after skin dermabrasion in induction of skin repigmentation in stable non-segmental vitiligo.
Patients and Methods: This study included thirty Egyptian patients, 18-60 years old, with stable non-segmental vitiligo. They were divided into: group [A] patients subjected to 5 fluorouracil after dermabrasion and group [B] patients subjected to latanoprost after dermabrasion then followed up every two weeks for three months.
 Result: There was no statistically significant difference between both groups regarding total response to treatment and degree of repigmentation. However, there was higher response to treatment in group A than group B. In both groups patients were satisfied with the degree of improvement. As regard complication there were minimal complications only one case of koebnerization and two cases of post inflammatory hyperpigmentation
Conclusion: 5- fluorouracil 5% was associated with better improvement than latanoprost. However, the difference did not reach statistical significance.  Patients reported high satisfaction with the two treatment modalities.

DOI

10.21608/ijma.2021.70410.1290

Keywords

Latanoprost, Five-fluorouracil, Vitiligo, dermabrasion

Authors

First Name

Rehab

Last Name

Abd El Razek

MiddleName

Basuny

Affiliation

Medical Administration Branch [For Girls], Al-Azhar University, Egypt

Email

m.rehab1188@gmail.com

City

-

Orcid

-

First Name

Zakaria

Last Name

Obaid

MiddleName

-

Affiliation

Department of Dermatology and Venereology, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

zakariamahran67@gmail.com

City

Cairo

Orcid

-

First Name

Osama

Last Name

Magdy Elshahat

MiddleName

-

Affiliation

Department of Dermatology and Venereology, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

elshabory@yahoo.com

City

-

Orcid

-

Volume

3

Article Issue

3

Related Issue

27050

Issue Date

2021-07-01

Receive Date

2021-03-31

Publish Date

2021-07-01

Page Start

1,550

Page End

1,555

Print ISSN

2636-4174

Online ISSN

2682-3780

Article File

IJMA_Volume 3_Issue 3_Pages 1550-1555.pdf

PDF . 1.9MB

Link

https://ijma.journals.ekb.eg/article_169689.html

Detail API

https://ijma.journals.ekb.eg/service?article_code=169689

Order

7

Type

Original Article

Type Code

816

Publication Type

Journal

Publication Title

International Journal of Medical Arts

Publication Link

https://ijma.journals.ekb.eg/

MainTitle

Comparative Study between Topical Latanoprost versus Topical 5- Fluorouracil after Dermabrasion for Treatment of Non-Segmental Stable Vitiligo

Details

Type

Article

Created At

22 Jan 2023