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159221

Prediction of Neonatal hyperbilirubinemia by The Cord Blood Alkaline ‎Phosphatase

Article

Last updated: 24 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Pediatrics

Abstract

Background: Owing to early discharge of neonates from the hospital, the readmission rate has been increased. Therefore, early detection of jaundice and prompt measures are important. Measurements of bilirubin and alkaline phosphatase levels in cord blood have been used for this function.   
The aim of the work: To assess the cord blood alkaline phosphatase value in predicting neonatal jaundice.
Patients and Methods: This study carried out during the period from August 2019 to January 2020 in pediatric department [Al-Azher University Hospital in Damietta]. This study included a total of 101 term infants with gestational age between 37 and 42 weeks, weighing more than 2500g born to healthy mothers. We performed an assessment of the complete medical history [maternal history and neonatal history]. Cord blood samples were collected for measurement of alkaline phosphatase. Neonates were followed-up for the emergence of jaundice. Infants with clinical jaundice were recalled and serum bilirubin level was measured. Significant indirect neonatal hyperbilirubinemia was considered.
Results: The study showed that patients with neonatal jaundice had statistically significant higher reticulocyte count, alkaline phosphate level and total bilirubin than patients without neonatal jaundice. However, the study shows the best cut-off points of regarding ALP to predict neonatal jaundice in neonates. A value of 200 or more IU/L was the best cut-off point to predict occurrence with a sensitivity of 98.3%, a specificity of 97.6%.
Conclusion: Increased alkaline phosphatase level in cord blood act as an indicator to neonatal jaundice, and may be used as a marker for early diagnosis.

DOI

10.21608/ijma.2021.48585.1200

Keywords

alkaline phosphatase, Enzyme, Bilirubin, Neonate, Hyperbilirubinemia

Authors

First Name

Esraa

Last Name

Farahat

MiddleName

G.

Affiliation

Department of Pediatrics, Damietta Faculty of Medicine, Al-Azhar University, Egypt.

Email

sunhope.122@gmail.com

City

-

Orcid

-

First Name

Hany

Last Name

El-khaleegy

MiddleName

A.

Affiliation

Department of Pediatrics, Damietta Faculty of Medicine, Al-Azhar University, Egypt.

Email

hanykhaleegy@yahoo.com

City

-

Orcid

-

First Name

Hesham

Last Name

Abd Al-samee

MiddleName

Samir

Affiliation

Department of Clinical Pathology, Damietta Faculty of Medicine, Al-Azhar University, Egypt.

Email

dr.hesham012@gmail.com

City

-

Orcid

27608151100155

First Name

Saad

Last Name

Mohamed

MiddleName

A.

Affiliation

Department of Pediatrics, Damietta Faculty of Medicine Al-Azhar University, Egypt.

Email

saaddawody@yahoo.com

City

-

Orcid

-

Volume

3

Article Issue

2

Related Issue

24821

Issue Date

2021-04-01

Receive Date

2020-11-02

Publish Date

2021-04-01

Page Start

1,429

Page End

1,436

Print ISSN

2636-4174

Online ISSN

2682-3780

Article File

IJMA_Volume 3_Issue 2_Pages 1429-1436.pdf

PDF . 1.6MB

Link

https://ijma.journals.ekb.eg/article_159221.html

Detail API

https://ijma.journals.ekb.eg/service?article_code=159221

Order

34

Type

Original Article

Type Code

816

Publication Type

Journal

Publication Title

International Journal of Medical Arts

Publication Link

https://ijma.journals.ekb.eg/

MainTitle

Prediction of Neonatal hyperbilirubinemia by The Cord Blood Alkaline ‎Phosphatase

Details

Type

Article

Created At

22 Jan 2023