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Effect of Magnesium Sulfate on Epinephrine-Mediated Adverse Effects during Liposuction Procedures: A prospective Randomized controlled Study

Article

Last updated: 04 Jan 2025

Subjects

-

Tags

Surgery

Abstract

Background: During liposuction procedures, injection of wetting solution containing epinephrine is performed. This may increase the risk of cardiovascular side effects in large volume cases. Magnesium sulfate has cardioprotective effects, and can prevent complications related to epinephrine.
The aim of the work: To assess the effect of adding intravenous magnesium sulfate, during the administration of epinephrine containing wetting solution, on the incidence of epinephrine-mediated cardiovascular side effects during liposuction surgery.
Patients and Methods: This was a prospective randomized study comprised a total of 94 cases into two equal groups. The epinephrine group included 47 cases that had epinephrine in their wetting solution, and epinephrine-Mg group included the remaining cases that had adrenaline in the wetting solution along with intra venous. administration of MgSO4. Heart rate, blood pressure, arrhythmia incidence, isoflurane, and morphine consumption were recorded. 
Results: No significant difference was noticed as regard basal and induction heart rate and mean arterial pressure [MAP]. However, the epinephrine-Mg group showed significantly lower readings on subsequent assessment. There was no significant difference among both groups regarding the incidence of arrhythmia; the epinephrine group had more cases with arrhythmia. Isoflurane consumption decreased significantly in the epinephrine-Mg group in comparison with the epinephrine group, while morphine consumption did not significantly differ between them.
Conclusion: Based on our findings, intravenous administration of magnesium sulfate decreases heart rate, blood pressure, and inhalational anesthesia consumption during liposuction. However, it has no significant impact neither on the incidence of arrhythmia, nor morphine consumption.

DOI

10.21608/ijma.2021.57348.1259

Keywords

Epinephrine, magnesium sulfate, liposuction, Arrhythmia, norepinephrine

Authors

First Name

Ahmed

Last Name

Sonbol

MiddleName

Mohammed

Affiliation

Department of Anesthesia and Intensive Care, Faculty of Medicine, Mansoura University, Egypt

Email

dr.sonbol@gmail.com

City

Mansoura

Orcid

0000-0002-5976-6705

First Name

Sameh

Last Name

Ghareeb

MiddleName

-

Affiliation

Department of Anesthesia and Intensive Care, Faculty of Medicine, Mansoura University, Egypt

Email

sameh926@yahoo.com

City

Damietta

Orcid

-

Volume

3

Article Issue

2

Related Issue

24821

Issue Date

2021-04-01

Receive Date

2021-02-08

Publish Date

2021-04-01

Page Start

1,390

Page End

1,397

Print ISSN

2636-4174

Online ISSN

2682-3780

Link

https://ijma.journals.ekb.eg/article_158326.html

Detail API

https://ijma.journals.ekb.eg/service?article_code=158326

Order

29

Type

Original Article

Type Code

816

Publication Type

Journal

Publication Title

International Journal of Medical Arts

Publication Link

https://ijma.journals.ekb.eg/

MainTitle

Effect of Magnesium Sulfate on Epinephrine-Mediated Adverse Effects during Liposuction Procedures: A prospective Randomized controlled Study

Details

Type

Article

Created At

22 Jan 2023