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116302

Neutrophil and Platelet to Lymphocyte Ratio for Detecting Early-onset Neonatal Sepsis

Article

Last updated: 24 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Pediatrics

Abstract

Background: Neonatal sepsis [NS] is associated with severe morbidity and mortality. Clinical manifestations range from subclinical infection to severe local or systemic infection. The diagnosis of NS remains a challenge as it has subtle and distinct signs and symptoms. Although blood culture is the gold standard in the diagnosis of NS, the search for high-sensitivity NS markers continues to overcome the drawbacks of blood cultures.   
The aim of the work: This study aimed to investigate the effectiveness of the neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in predicting early onset sepsis in neonates.
Patients and Methods: A case control study, comprised 120 newborns [60 newborns with neonatal sepsis as a case group and 60 healthy newborns as a control group], based on patient records at neonatal intensive care unit [NICU] of Al-Azhar University Hospital [Damietta], from January 2018 to January 2019. All were subjected to adequate history taking, full clinical examination, complete blood picture, C-reactive protein and blood culture. After that, neutrophil to lymphocyte ratio [NLR] and platelet to lymphocyte ratio [PLR] were calculated.
Results: NLR was significantly higher in neonates with sepsis. However, there were no association between PLR and early onset sepsis [EOS]. Although, the diagnostic cutoff value for NLR was 1.0 with 72% sensitivity, 100% specificity, there was no association between PLR and EOS.
Conclusion: NLR increases significantly in neonatal sepsis, and can be used as a marker for detection of early onset neonatal sepsis.

DOI

10.21608/ijma.2020.21844.1069

Keywords

Neonate, Early onset sepsis, Neutrophil lymphocyte ratio, Platelet lymphocyte ratio

Authors

First Name

Sara

Last Name

Mira

MiddleName

Mohamed

Affiliation

Department of Pediatrics, Ministry of Health, Egypt

Email

khaled191081@yahoo.com

City

Mansoura

Orcid

-

First Name

Hany

Last Name

Alkhalegy

MiddleName

Abd-elhady

Affiliation

Department of Pediatrics, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

hanykhalgy@yahoo.com

City

New Damietta

Orcid

-

First Name

Sabah

Last Name

Abd-Elraheem

MiddleName

Ibrahim

Affiliation

Department of Clinical Pathology, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

drsabahibrahim@yahoo.com

City

Damietta

Orcid

-

First Name

Elbakry

Last Name

Elbakry

MiddleName

Mohamed Tharwat

Affiliation

Department of Pediatrics, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

drbakry@gmail.com

City

new damiatte

Orcid

-

Volume

3

Article Issue

2

Related Issue

24821

Issue Date

2021-04-01

Receive Date

2020-01-02

Publish Date

2021-04-01

Page Start

1,274

Page End

1,281

Print ISSN

2636-4174

Online ISSN

2682-3780

Article File

IJMA_Volume 3_Issue 2_Pages 1274-1281.pdf

PDF . 1.3MB

Link

https://ijma.journals.ekb.eg/article_116302.html

Detail API

https://ijma.journals.ekb.eg/service?article_code=116302

Order

15

Type

Original Article

Type Code

816

Publication Type

Journal

Publication Title

International Journal of Medical Arts

Publication Link

https://ijma.journals.ekb.eg/

MainTitle

Neutrophil and Platelet to Lymphocyte Ratio for Detecting Early-onset Neonatal Sepsis

Details

Type

Article

Created At

22 Jan 2023