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142495

Comparative Study Between the Efficacy of Microneedling Combined with Trichloroacetic Acid Versus Microneedling with Tacrolimus in the Treatment of Stable Vitiligo

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Dermatology

Abstract

Background: Many treatment options were used for Vitiligo. But there is no consensus on the precise treatment modality.  
Aim of the work: The study aimed to assess and compare the efficacy of microneedling combined with trichloracetic acid [TCA] versus micro-needling with tacrolimus in the treatment of Vitiligo,
Patients and Methods: 60 Vitiligo were included and classified into two equal groups. Group [A] included 30 patients who received micro-needling with dermapen then tacrolimus 0.03 ointments every two weeks for six sessions. Group B included thirty patients who received micro-needling with dermapen then TCA 25% every two weeks for six sessions. The outcome was documented.  
Results: The repigmentation was slightly higher in TCA-treated patches than with tacrolimus. Excellent response in repigmentation occurred in 43.3%of TCA patches. In contrast, in 16.7% of tacrolimus-treated patches, Good improvement occurred in13.3% of TCA-treated patches while 23.3% of tacrolimus-treated patches. Moderate improvement occurred in10.0% TCA -treated patches while 30.0% of tacrolimus-treated patches, mild improvement occurred in 13.3% of TCA -treated patches. In comparison, only in 16.7% of tacrolimus-treated patches, However, there was a great difference between the two drugs regarding erythema, inflammation, and exfoliations, which occurred mainly with TCA.
Conclusion: The mix of microneedling with either TCA 25% or tacrolimus is effective and safe in treating Vitiligo. However, TCA achieved a slightly increased percentage of repigmentation than tacrolimus.

DOI

10.21608/ijma.2021.48137.1205

Keywords

Vitiligo, Response, Microneedling, Tacrolimus, TCA

Authors

First Name

Rofaida

Last Name

Elnokaly

MiddleName

Mohamed

Affiliation

Department of Dermatology, Faculty of Medicine, Al-Azhar University, Egypt

Email

rofydaelnukaly@yahoo.com

City

port said

Orcid

-

First Name

Osama

Last Name

SayedAhmed

MiddleName

Magdy Elshahat

Affiliation

Department of Dermatology, Damietta Faculty of Medicine, Al-Azhar University, Egyp

Email

elshabory@yahoo.com

City

-

Orcid

-

First Name

Hassan

Last Name

Mohamed

MiddleName

Abou Khodair

Affiliation

Department of Dermatology, Damietta Faculty of Medicine, Al-Azhar University, Egyp

Email

drhassankhodair@gmail.com

City

-

Orcid

-

Volume

3

Article Issue

2

Related Issue

24821

Issue Date

2021-04-01

Receive Date

2020-11-09

Publish Date

2021-04-01

Page Start

1,188

Page End

1,194

Print ISSN

2636-4174

Online ISSN

2682-3780

Article File

IJMA_Volume 3_Issue 2_Pages 1188-1194.pdf

PDF . 1.4MB

Link

https://ijma.journals.ekb.eg/article_142495.html

Detail API

https://ijma.journals.ekb.eg/service?article_code=142495

Order

4

Type

Original Article

Type Code

816

Publication Type

Journal

Publication Title

International Journal of Medical Arts

Publication Link

https://ijma.journals.ekb.eg/

MainTitle

Comparative Study Between the Efficacy of Microneedling Combined with Trichloroacetic Acid Versus Microneedling with Tacrolimus in the Treatment of Stable Vitiligo

Details

Type

Article

Created At

22 Jan 2023