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140633

Association between Gastroesophageal Reflux Disease and Chronic Sinusitis: Salivary and Nasal Pepsin as a Biomarker

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Otorhinolaryngology

Abstract


Background: The relationship between gastroesophageal reflux [GER] and chronic rhinosinusitis [CRS] has been discussed in several studies, but a direct relationship could not be established. However, both conditions are highly prevalent.   
Aim of the work: The study aimed to evaluate the nasal and salivary pepsin as a biomarker for GER in CRS patients.
Patients and Methods: Fifty patients with CRS were included; 28 males and 22 females, and 50 healthy volunteers; 25 males and 25 females served as controls. Peptest was performed for all subjects.
Results: Pepsin positivity was found to have a slight increase in CRS salivary samples than the control group. However, the difference was insignificant  [P >0.05], in contrast with nasal samples, which was estimated to have a statistically significant difference [P <0.05] in the second and third samples. As regard pepsin concentration in salivary samples, it was found to show a statistically significant difference [P <0.01] in all samples, while it was non-significant in all nasal samples [P>0.05].
Conclusion: CRS patients have a higher positive rate of pepsin in salivary and nasal secretions; however, no significant more pepsin in saliva or nasal secretions is regarded as CRS-patients than healthy controls.

DOI

10.21608/ijma.2021.47667.1197

Keywords

Chronic Rhinosinusitis, Salivary, nasal, Pepsin, Gastroesophageal reflux disease

Authors

First Name

Mohamed

Last Name

Abdelazim

MiddleName

Hussein

Affiliation

Department of Otorhinolaryngology, Dameitta Faculty of Medicine, Al-Azhar University, Egypt

Email

mohammedabdelazeem35@yahoo.com

City

Kafr Elsheikh

Orcid

-

First Name

Ahmed

Last Name

Ibrahim

MiddleName

Abd-alrahman

Affiliation

Department of Otorhinolaryngology, Dameitta Faculty of Medicine, Al-Azhar University, Egypt

Email

dr.ahmedent@yahoo.com

City

New Dameitta

Orcid

-

First Name

Amr

Last Name

El-hakeem

MiddleName

Mohammed

Affiliation

Department of Clinical Pathology, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

amrhakeem0@gmail.com

City

New Dameitta

Orcid

-

Volume

3

Article Issue

2

Related Issue

24821

Issue Date

2021-04-01

Receive Date

2020-10-25

Publish Date

2021-04-01

Page Start

1,181

Page End

1,187

Print ISSN

2636-4174

Online ISSN

2682-3780

Article File

IJMA_Volume 3_Issue 2_Pages 1181-1187.pdf

PDF . 1.3MB

Link

https://ijma.journals.ekb.eg/article_140633.html

Detail API

https://ijma.journals.ekb.eg/service?article_code=140633

Order

3

Type

Original Article

Type Code

816

Publication Type

Journal

Publication Title

International Journal of Medical Arts

Publication Link

https://ijma.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023