Beta
ManageSearchChatDiscover
130873

Protective Effect of Cinnamon and Ginger on Acrylamide Induced Hepatotoxicity in Adult Male Albino Rats

Article

Last updated: 24 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Basic Sciences

Abstract

Background:Background: Acrylamide [ACR] is an essential chemical that is extensively used in many industries and also in laboratories such as treatment of drinking water, wastewater, and soil, production of paper, petroleum, mine, asphalt, dyes, adhesives, and polishes; it is known as a possible carcinogenic compound. Ginger oleoresin's hepatoprotective role can be attributed to its free radical scavenging, anti-inflammatory, and hypolipidemic activities and is partially mediated by the 6-gingerol, shogaol, and zingerone of its active component. Cinnamomum zeylanicum is used to treat many diseases and to prevent such diseases.
Aim of the work:Evaluation of the effects of cinnamon and ginger extracts administration on Hepatotoxicity adult male albino rats.
Materials and Methods: The groups were divided into five adult male albino rats of a local strain: Group I: acted as a control group with regular salines, group II: hepatotoxicity caused by acrylamid, groups III: hepatotoxicity plus cinnamon, group IV: hepatotoxicity plus ginger, group V: hepatotoxicity plus cinnamon and ginger. Samples for alanine aminotransferase [ALT], aspartate transfers of amino [AST], urea, creatinine, blood urea nitrogen (BUN), total cholesterol, triglyceride [TG], malondialdehyde, tumor necrosis factor α [TNF], superoxide dismutase [SOD], glutathione peroxidase [GPX], as well as total antioxidant [TAC] levels were obtained at the end of the experimental period. 
Results: Administration of cinnamon and ginger to hepatotoxic rats led to a significant decrease in the mean value of ALT, AST, urea, creatinine, BUN, MDA, and TNF. In addition, it is associated with a significant increase of SOD, GPX, and TAC.
 Conclusion: Cinnamon and ginger have a protective effect against abnormalities in hepatotoxic rats due to its several protective properties.

DOI

10.21608/ijma.2020.43688.1177

Keywords

acrylamide, Ginger, Cinnamon, Hepatotoxicity, albino

Authors

First Name

El-sayed

Last Name

El-sayed Gawesh

MiddleName

Hamdey

Affiliation

Department of Forensic Medicine and Clinical Toxicology, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

sayedgawesh1010@yahoo.com

City

Kafr ElSheikh

Orcid

-

First Name

Ahmed

Last Name

Abdelreheem Elshoura

MiddleName

Ibrahim

Affiliation

Department of Forensic Medicine and Clinical Toxicology, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

ahmedishoura@gmail.com

City

Mansura

Orcid

-

First Name

Mohamed

Last Name

Abbas

MiddleName

Ali

Affiliation

Department of Medical Physiology, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

drmohamedali122@gmail.com

City

New-Damietta

Orcid

-

Volume

3

Article Issue

1

Related Issue

21557

Issue Date

2021-01-01

Receive Date

2020-09-21

Publish Date

2021-01-01

Page Start

1,136

Page End

1,144

Print ISSN

2636-4174

Online ISSN

2682-3780

Article File

IJMA_Volume 3_Issue 1_Pages 1136-1144.pdf

PDF . 1.8MB

Link

https://ijma.journals.ekb.eg/article_130873.html

Detail API

https://ijma.journals.ekb.eg/service?article_code=130873

Order

32

Type

Review Article

Type Code

817

Publication Type

Journal

Publication Title

International Journal of Medical Arts

Publication Link

https://ijma.journals.ekb.eg/

MainTitle

Protective Effect of Cinnamon and Ginger on Acrylamide Induced Hepatotoxicity in Adult Male Albino Rats

Details

Type

Article

Created At

22 Jan 2023