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125767

Evaluation of Serum Insulin, Glucose and Liver Function in β-Thalassemia Major and Their Correlation with Iron Overload

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Pediatrics

Abstract

Background: Beta-thalassemia syndromes are a set of hereditary blood disorders marked by a deficiency of beta-globin chain synthesis, resultant in decrease hemoglobin in red blood cells [RBC], anemia, and a reduced RBC production
Aim of the work: To evaluate glycometabolic and liver function in cases with β-thalassemia major and their correlation with serum iron and ferritin
Patients and methods: This was a case-control study that was performed in the pediatric department of Al-Azher University Hospital in Damietta from June 2018 to June 2019. Fasting serum glucose, insulin, and liver enzymes were assessed for 48 cases and 40 ordinary controls. Serum iron and ferritin were recorded as an indicator of iron overload
Results: Fasting serum insulin, alanine transaminase [ALT] levels, aspartate transaminase [AST] levels were significantly high in thalassemia major [TM] cases than in the control group [p
Conclusion: The kids with β-TM have a high glycemic disorders incidence rate, may be because of the insulin resistance due to the amplified iron burden.

DOI

10.21608/ijma.2020.43776.1179

Keywords

β thalassemia major (TM), Serum Insulin, glucose, iron overload

Authors

First Name

Basma

Last Name

Matar

MiddleName

Mohammed

Affiliation

Department of Pediatrics, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

basmamohammed305@gmail.com

City

-

Orcid

-

First Name

Magdy

Last Name

Sakr

MiddleName

Mohamed Ashmawy

Affiliation

Department of Pediatrics, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

sakrmagdy@hotmail.com

City

Cairo

Orcid

-

First Name

Lotfy

Last Name

Alsehaimy

MiddleName

AbdElfattah

Affiliation

Department of Pediatrics, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

dr_lutfy@yahoo.com

City

-

Orcid

-

First Name

Hesham

Last Name

Abd al-samee

MiddleName

Samir

Affiliation

Department of Clinical Pathology, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

dr.hesham012@gmail.com

City

-

Orcid

27608151100155

Volume

3

Article Issue

1

Related Issue

21557

Issue Date

2021-01-01

Receive Date

2020-09-22

Publish Date

2021-01-01

Page Start

1,088

Page End

1,096

Print ISSN

2636-4174

Online ISSN

2682-3780

Article File

IJMA_Volume 3_Issue 1_Pages 1088-1096.pdf

PDF . 1.9MB

Link

https://ijma.journals.ekb.eg/article_125767.html

Detail API

https://ijma.journals.ekb.eg/service?article_code=125767

Order

26

Type

Original Article

Type Code

816

Publication Type

Journal

Publication Title

International Journal of Medical Arts

Publication Link

https://ijma.journals.ekb.eg/

MainTitle

Evaluation of Serum Insulin, Glucose and Liver Function in β-Thalassemia Major and Their Correlation with Iron Overload

Details

Type

Article

Created At

22 Jan 2023