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125159

Intrathecal Fentanyl versus Dexmedetomedine as Adjuvants to Bupivacaine for Cesarean Section

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Surgery

Abstract

Background: Intrathecal α2 agonists prolong the duration of action of local anesthetics and reduce the required dose. Dexmedetomidine is an α2 receptor agonist, and its α2/α1 selectivity is eight times higher than that of clonidine
Aim of the work:  This study aimed to determine the effect of adding dexmedetomidine or fentanyl to intrathecal bupivacaine on the onset time, duration, and intensity of motor and sensory blocks as the primary outcome and postoperative analgesia, sedation, and incidence of side effects as a secondary outcome in cesarean section.
Patients and methods: The study was carried out on 40 adults full-term pregnant female submitted for elective cesarean section were randomly classified into two equal groups, twenty patients each: Group [D]: Patients received intrathecally bupivacaine and dexmedetomidine. Group [F]: Patients received intrathecally bupivacaine and fentanyl.
Results: Sensory and motor block onset times were shorter in Group D than in Group F. The regression of the sensory block to S1 dermatome and Bromage 0 were longer in Group D than in Group F. The two-dermatome regression time was longer in Group D than in Group F. There was a statistically significant decrease in group F regarding systolic, diastolic, mean arterial blood pressure, and heart rate than in group D. The postoperative analgesic effect time was longer in group D than in group F. Neonatal outcome was normal in all groups
Conclusion: We concluded that adding intrathecal dexmedetomidine to bupivacaine for spinal anesthesia synergistically increase block duration and shortens sensory and motor block onset time with better postoperative analgesia without any significant adverse effects.

DOI

10.21608/ijma.2020.23709.1097

Keywords

Spinal anesthesia, Bupivacaine, Caesarean section, Dexmedetomidine, Fentanyl

Authors

First Name

Tawfik

Last Name

Noor El-Din

MiddleName

-

Affiliation

Department of Anesthesia and Intensive Care, Faculty of Medicine, Al-Azhar University, Egypt

Email

tawfeeknoor59@gmail.com

City

-

Orcid

-

First Name

Mostafa

Last Name

Hussien

MiddleName

-

Affiliation

Department of Anesthesia and Intensive Care, Faculty of Medicine, Al-Azhar University [Assiut Branch], Egypt

Email

mostafahussien@gmail.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Abd El-Galil

MiddleName

-

Affiliation

Department of Anesthesia and Intensive Care, Faculty of Medicine, Al-Azhar University, Egypt

Email

dr.ahmed.abdelgleel@gmail.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Abd ellatif

MiddleName

Emad

Affiliation

Department of Anesthesia and Intensive Care, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

omda433@gmail.com

City

-

Orcid

-

Volume

3

Article Issue

1

Related Issue

21557

Issue Date

2021-01-01

Receive Date

2020-02-08

Publish Date

2021-01-01

Page Start

1,083

Page End

1,087

Print ISSN

2636-4174

Online ISSN

2682-3780

Article File

IJMA_Volume 3_Issue 1_Pages 1083-1087.pdf

PDF . 1.6MB

Link

https://ijma.journals.ekb.eg/article_125159.html

Detail API

https://ijma.journals.ekb.eg/service?article_code=125159

Order

25

Type

Original Article

Type Code

816

Publication Type

Journal

Publication Title

International Journal of Medical Arts

Publication Link

https://ijma.journals.ekb.eg/

MainTitle

Intrathecal Fentanyl versus Dexmedetomedine as Adjuvants to Bupivacaine for Cesarean Section

Details

Type

Article

Created At

22 Jan 2023