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Safety and Efficacy of Sofosbuvir and Daclatasvir in The Treatment of Chronic HCV Infection in Elderly Egyptian Patients

Article

Last updated: 24 Dec 2024

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Tags

Internal Medicine

Abstract

Background: Chronic Hepatitis-C virus [HCV] infection is endemic in Egypt, with the highest prevalence worldwide. There are few studies on the effectiveness and safety of direct acting antivirals in treating geriatric patients with chronic HCV.
Aim of the work: This study aimed to determine the efficacy and safety of sofosbuvir and daclatasvir with or without ribavirin in treating chronic HCV infection in geriatric Egyptian patients.
Patients and Methods: In this study, we analyzed the medical files of 100 patients with chronic HCV, ≥ 65 years old, naïve, and eligible for HCV treatment. Patients were classified into: Group I; 50 patients without cirrhosis and Group II; 50 patients with Cirrhosis. All patients were subjected to history taking, clinical and laboratory evaluation. Electrocardiogram [ECG] and echocardiography were also conducted. Polymerase chain reaction [PCR] for HCV- ribonucleic acid [RNA] was performed and compared between groups at baseline, at the end of treatment, and at 12 weeks later. All patients underwent an abdominal ultrasound and fibrosis-4 [FIB-4] score. Group I was treated with sofosbuvir 400 mg and daclatasvir 60 mg once daily for 12 weeks, while weight-based ribavirin was added in group II.
Results: Overall, 95 patients achieved sustained virological response[SVR]-12, three had failed treatment, and two had relapse. There were no significant differences in treatment success between the groups after treatment completion [HCV RNA was below the detection limit in 49 patients in group I and 48 patients in group II] and 12 weeks later [HCV RNA was below the detection limit in 48 patients in group I and 47 patients in group II], with one patient in group I and two patients in group II had failed treatment. There was also a significant decrease in alanine transaminase [ALT] and aspartate transaminase [AST] in both groups after treatment completion. Some patient symptoms like easy fatigability and dyspepsia have been improved with no significant cardiac changes after therapy.
Conclusions: Sofosbuvir and daclatasvir with or without ribavirin are safe and effective in treating elderly Egyptian patients with chronic HCV infection.

DOI

10.21608/ijma.2020.46788.1195

Keywords

Egyptians, Hepatitis-C virus, Sofosbuvir, Daclatasvir, Elderly

Authors

First Name

Mohamed G.

Last Name

Mohamed

MiddleName

-

Affiliation

Department of Hepatogastroenetrology and Infectious Diseases, Faculty of Medicine, Al-Azhar University, Egypt

Email

dr_ghreep90@azhar.edu.eg

City

Ad dlingat

Orcid

-

First Name

Mohamed B.

Last Name

Bastawy

MiddleName

-

Affiliation

Department of Hepatogastroenetrology and Infectious Diseases, Faculty of Medicine, Al-Azhar University, Egypt

Email

mohamedbastawi@hotmail.com

City

Cairo

Orcid

-

First Name

Mostafa A.

Last Name

Elhawary

MiddleName

-

Affiliation

Department of Hepatogastroenetrology and Infectious Diseases, Faculty of Medicine, Al-Azhar University, Egypt

Email

hawwary67@yahoo.com

City

Cairo

Orcid

-

First Name

Mohamed R.

Last Name

Rashed

MiddleName

-

Affiliation

Department of Hepatogastroenetrology and Infectious Diseases, Faculty of Medicine, Al-Azhar University, Egypt

Email

mohammedrashed335@gmail.com

City

Cairo

Orcid

-

Volume

3

Article Issue

1

Related Issue

21557

Issue Date

2021-01-01

Receive Date

2020-10-18

Publish Date

2021-01-01

Page Start

1,053

Page End

1,059

Print ISSN

2636-4174

Online ISSN

2682-3780

Article File

IJMA_Volume 3_Issue 1_Pages 1053-1059.pdf

PDF . 1.8MB

Link

https://ijma.journals.ekb.eg/article_122310.html

Detail API

https://ijma.journals.ekb.eg/service?article_code=122310

Order

21

Type

Original Article

Type Code

816

Publication Type

Journal

Publication Title

International Journal of Medical Arts

Publication Link

https://ijma.journals.ekb.eg/

MainTitle

Safety and Efficacy of Sofosbuvir and Daclatasvir in The Treatment of Chronic HCV Infection in Elderly Egyptian Patients

Details

Type

Article

Created At

22 Jan 2023