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Prevalence and Clinical Significance of Factor V Leiden Mutation in Egyptian Preeclamptic Women

Article

Last updated: 04 Jan 2025

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Subjects

-

Tags

Gynecology and Obstetrics

Abstract

Background: Factor V [Leiden] mutation, also known as activated protein-C resistance, is the most common of the inherited thrombophilias.
Aim of the work: The present study aimed to ass the prevalence of factor V Leiden mutation in a group of Egyptian pregnant women and its relation to maternal and neonatal outcomes.
Patients and methods: The present prospective study included 130 preeclamptic women with a singleton pregnancy in the 3rd trimester. Blood samples were obtained for DNA analysis to assay factor V Leiden mutation. Transabdominal obstetric ultrasound examination was performed to confirm the fetal number, viability, presentation, estimated fetal weight, position & grade of the placenta, amount of liquor, biophysical profile, and gestational age. This was achieved through the measurements of the biparietal diameter, head circumference, abdominal circumference, and femur length. Flow velocity waveforms were obtained from each uterine artery.
Results: Factor V Leiden [FVL] mutation was identified in 20 patients [15.4 %]. Comparison between women with FVL and women without revealed a significantly higher frequency of intrauterine growth restriction [IUGR], intrauterine fetal death  [IUFD], small for gestational age [SGA], preterm labor, and intensive care unit [ICU] admission among women with FVL mutation. They also have a significantly higher frequency of abnormal Doppler findings, abruptio placenta, and placental infarction.
Conclusion: The present study suggested that maternal and neonatal complications in PE patients may be related to FVL, abnormal uterine artery Doppler findings, and placental infarction.

DOI

10.21608/ijma.2020.39091.1155

Keywords

Factor V Leiden, preeclampsia, uterine artery Doppler, Mutation, Egyptian

Authors

First Name

Ahmed

Last Name

Alsheikh

MiddleName

Mohamed

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University, Egypt

Email

dr.ahmed.201053@gmail.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Elsadek

MiddleName

Mohammed

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University, Egypt

Email

dr.ahmedelsadek84@gmail.com

City

-

Orcid

-

First Name

Samy

Last Name

Gebreel

MiddleName

Amin

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University, Egypt

Email

samy.gebreel@outlook.com

City

-

Orcid

-

Volume

3

Article Issue

1

Related Issue

21557

Issue Date

2021-01-01

Receive Date

2020-08-16

Publish Date

2021-01-01

Page Start

1,033

Page End

1,038

Print ISSN

2636-4174

Online ISSN

2682-3780

Article File

IJMA_Volume 3_Issue 1_Pages 1033-1038.pdf

PDF . 1.7MB

Link

https://ijma.journals.ekb.eg/article_121247.html

Detail API

https://ijma.journals.ekb.eg/service?article_code=121247

Order

18

Type

Original Article

Type Code

816

Publication Type

Journal

Publication Title

International Journal of Medical Arts

Publication Link

https://ijma.journals.ekb.eg/

MainTitle

Prevalence and Clinical Significance of Factor V Leiden Mutation in Egyptian Preeclamptic Women

Details

Type

Article

Created At

22 Jan 2023