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Relationship between Vitamin-D Receptor Gene Polymorphism FokI and Fetuin- A as A marker of Vascular Calcification in Egyptian Hemodialysis Patients

Article

Last updated: 24 Dec 2024

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Subjects

-

Tags

Internal Medicine

Abstract

Background: Vascular calcification is a common complication in end-stage renal disease patients and the leading cause of morbidity and mortality.
Aim of the work: The current work aimed to evaluate the possible relationship between vitamin D receptor gene polymorphism FokI with fetuin-A and intact parathormone hormone in Egyptian hemodialysis patients.
Patient and Methods: This study is a cross-sectional study including 50 hemodialysis patients attending the hemodialysis unit in Al-Zahra University Hospital and 30 apparently healthy persons as a control group. For all studied subjects, a detailed history was taken, physical examination, carotid intima-media thickness by carotid duplex, echocardiography, Laboratory investigations included serum levels of calcium, phosphorus, iPTH, fetuin, and genotype frequency by PCR
Results: There was a highly significant increase in carotid intimal media thickness in the patient group Vs. control group & a highly significant decrease in serum Fetuin-A in the patient's group Vs. control group. There was a significant difference in the genotype distribution of FokI polymorphism among patients and control. There were significant negative relationships between FF genotype and iPTH and a highly significant negative correlation between serum fetuin-A and iPTH in the patient group.
Conclusion: Vitamin D receptor gene FokI polymorphism FF genotyping is more frequent in hemodialysis patients who have higher iPTH and lower fetuin-A levels, which could identify the high-risk group susceptible to vascular calcification in hemodialysis patients. Further studies are needed.

DOI

10.21608/ijma.2020.31335.1130

Keywords

vascular calcification, Vitamin D receptor polymorphism, FokI, Fetuin-A, Parathormone hormone

Authors

First Name

Fatma Ibrahim

Last Name

Mayah

MiddleName

-

Affiliation

Department of Internal Medicine, Faculty of Medicine for Girls, Al Azhar University, Egypt

Email

fatmamayah343@yahoo.com

City

Cairo

Orcid

-

First Name

Hayam Hamza

Last Name

Mansour

MiddleName

-

Affiliation

Department of Internal Medicine, Faculty of Medicine for Girls, Al Azhar University, Egypt

Email

drhayam1971@gmail.com

City

Cairo

Orcid

-

First Name

Ragaa Ramadan

Last Name

Mohamed

MiddleName

-

Affiliation

Department of Internal Medicine, Faculty of Medicine for Girls, Al Azhar University, Egypt

Email

drragaamohamed@yahoo.com

City

Cairo

Orcid

-

First Name

Nadia Kamal

Last Name

Marey

MiddleName

-

Affiliation

Department of Internal Medicine, Faculty of Medicine for Girls, Al Azhar University, Egypt

Email

dr.nadia.marie@yahoogmail.com

City

Cairo

Orcid

-

First Name

Khaled Younis

Last Name

Mohammed

MiddleName

younis

Affiliation

Department of Internal Medicine National Research Center, Egypt

Email

k_younes@hotmail.com

City

Cairo

Orcid

-

First Name

Amr Mohamed

Last Name

Ibrahim

MiddleName

-

Affiliation

Department of Clinical Pathology National Research Center, Egypt

Email

amrmmm64@hotmail.com

City

Cairo

Orcid

-

First Name

Tarek Fakhr eldeen

Last Name

Osman

MiddleName

-

Affiliation

Department of Nephrology, National Institute of Urology and Nephrology, Egypt

Email

tarekfakhrosman@0utlook.com

City

-

Orcid

-

Volume

3

Article Issue

1

Related Issue

21557

Issue Date

2021-01-01

Receive Date

2020-05-30

Publish Date

2021-01-01

Page Start

967

Page End

975

Print ISSN

2636-4174

Online ISSN

2682-3780

Article File

IJMA_Volume 3_Issue 1_Pages 967-975.pdf

PDF . 1.2MB

Link

https://ijma.journals.ekb.eg/article_109400.html

Detail API

https://ijma.journals.ekb.eg/service?article_code=109400

Order

10

Type

Original Article

Type Code

816

Publication Type

Journal

Publication Title

International Journal of Medical Arts

Publication Link

https://ijma.journals.ekb.eg/

MainTitle

Relationship between Vitamin-D Receptor Gene Polymorphism FokI and Fetuin- A as A marker of Vascular Calcification in Egyptian Hemodialysis Patients

Details

Type

Article

Created At

22 Jan 2023