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103311

Effect of Zinc Supplementation on Serum Bilirubin Level in Term Neonates Undergoing Phototherapy

Article

Last updated: 22 Jan 2023

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-

Tags

Pediatrics

Abstract

Background: Neonatal jaundice is considered a major health problem in neonates owing to bilirubin deposition. Recently, zinc demonstrated a high efficiency in reduction of low bilirubin level when administrated in association with phototherapy.
Aim of the work: To assess efficiency and safety of oral zinc as a therapy in treatment of indirect hyperbilirubinemia in term neonates during phototherapy.
Patients and Methods:A total of 100 term neonates with indirect hyperbilirubinemia were divided into two equal groups: Intervention Group (n=50) received oral zinc sulphate preparation, in a dose of 5 mg twice daily in combination with phototherapy. Control group (n=50) received phototherapy without oral zinc supplementation. In both groups, the total serum bilirubin levels were measured at admission, 12 hours, 24 hours and at discharge.
Results: Treatment of full-term neonates with hyperbilirubinemia by oral zinc sulfate at a dose of 5 mg given twice-daily induce a significant reduction of  total serum bilirubin [TSB] after 12 hours, 24 hours and at discharge when compared to the control group. The duration of phototherapy in intervention group was markedly decreased with statistically significant difference in comparison to the control group. However, there was no significant differences between groups regarding adverse effects of phototherapy and zinc therapy.
Conclusion: Oral zinc could play a major role in the management of neonatal jaundice when administrated at dose of ten mg/day as it can decrease the neonatal TSB with subsequent reduction of phototherapy duration.

DOI

10.21608/ijma.2020.31551.1131

Keywords

Neonatal Jaundice, Hyperbilirubinemia, zinc, phototherapy, Total serum bilirubin

Authors

First Name

Mahmoud Eldesoky

Last Name

Ibrahim Eldesoky

MiddleName

-

Affiliation

Department of Pediatrics, Damietta Faculty of Medicine, Al-Azhar University, Egypt.

Email

mahmoudeldesoky707@gmail.com

City

Mansoura

Orcid

-

First Name

Mohamed Ibrahim

Last Name

El-Samannody

MiddleName

-

Affiliation

Department of Pediatrics, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

mohamed_elsamanody@yahoo.com

City

Tanta

Orcid

27801011202238

First Name

Magdy

Last Name

Elghannam

MiddleName

Zaky

Affiliation

Department of Clinical Pathology, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

mzm.alghannam@domazhermedicine.edu.eg

City

Mansoura

Orcid

-

First Name

Mohamed Mohamed

Last Name

Elmazahy

MiddleName

-

Affiliation

Department of Pediatrics, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

m_mazahi@hotmail.com

City

-

Orcid

-

Volume

2

Article Issue

4

Related Issue

17986

Issue Date

2020-10-01

Receive Date

2020-06-01

Publish Date

2020-10-01

Page Start

736

Page End

740

Print ISSN

2636-4174

Online ISSN

2682-3780

Article File

IJMA_Volume 2_Issue 4_Pages 736-740.pdf

PDF . 2.2MB

Link

https://ijma.journals.ekb.eg/article_103311.html

Detail API

https://ijma.journals.ekb.eg/service?article_code=103311

Order

9

Type

Original Article

Type Code

816

Publication Type

Journal

Publication Title

International Journal of Medical Arts

Publication Link

https://ijma.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023