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Magnesium Sulfate versus Nitroglycerin in Controlled Hypotensive Anesthesia in Middle Ear Surgeries

Article

Last updated: 04 Jan 2025

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Subjects

-

Tags

Surgery

Abstract

Background: Controlled hypotension is required for middle ear surgeries to achieve a bloodless operative field and improve its quality, both magnesium sulfate and nitroglycerine used to produce deliberate hypotension. 
Aim of the work: This study aimed to compare the efficacy of magnesium sulfate and nitroglycerin in inducing controlled hypotensive anesthesia as a primary outcome and using propranolol if tachycardia occurred as a secondary outcome, in middle ear surgeries.
Patients and Methods:The study was carried out on 40 adults' patients were randomly classified into two equal groups, twenty patients each: Group [M]: Received an intravenous [IV] bolus of magnesium sulfate 30 mg/ kg in 100 ml saline over 10 min followed by infusion of 10 mg/kg/h. Group [N]: Received nitroglycerin IV infusion 0.5-10 mcg/kg/min.
Propranolol 1- 2.5 mg IV had been given to both groups if there was tachycardia.
Results: Both drugs induced hypotension with statistically significant difference in systolic and mean blood pressure [BP] and there was highly significant increase in heart rate [HR] in nitroglycerin more than magnesium sulfate and high doses of propranolol were administrated in nitroglycerine group. Postoperative pain was significantly increased in nitroglycerin than magnesium sulfate groups which had more analgesic effect.
Conclusion: Both drugs induced hypotension. However, magnesium sulfate was better as it provided optimum surgical field, less tachycardia, need less dose of propranolol with less post-operative pain in comparison to nitroglycerin

DOI

10.21608/ijma.2020.23757.1098

Keywords

Nitroglycerin, Magnesium sulphate, Hypotensive agents, Middle Ear, Surgery

Authors

First Name

Tawfik

Last Name

Noor El-Din

MiddleName

Mohamed

Affiliation

Department of Anesthesia and Intensive Care, Faculty of Medicine, Al-Azhar University, Cairo.

Email

tawfeeknoor59@gmail.com

City

Cairo Egypt

Orcid

-

First Name

Mahmoud

Last Name

Madian

MiddleName

Fathi

Affiliation

Department of Anesthesia and Intensive Care, Faculty of Medicine, Al-Azhar University, Assuit

Email

mahmoudmadian12@gmail.com

City

Banha - Qalybia

Orcid

-

First Name

Eman

Last Name

Salem

MiddleName

Ahmed

Affiliation

Department of Anesthesia and Intensive Care, Faculty of Medicine, Al-Azhar University, Cairo for girls

Email

eman_salem73@hotmail.com

City

Cairo Egypt

Orcid

-

First Name

Ahmed

Last Name

Hamed

MiddleName

Hamdy

Affiliation

Anesthesia and ICU Department, Faculty of medicine, Alazhar university Damietta

Email

ahhamdy2525@gmail.com

City

-

Orcid

-

Volume

2

Article Issue

3

Related Issue

16043

Issue Date

2020-07-01

Receive Date

2020-02-09

Publish Date

2020-07-01

Page Start

661

Page End

667

Print ISSN

2636-4174

Online ISSN

2682-3780

Article File

IJMA_Volume 2_Issue 3_Pages 661-667.pdf

PDF . 281.2kB

Link

https://ijma.journals.ekb.eg/article_100625.html

Detail API

https://ijma.journals.ekb.eg/service?article_code=100625

Order

26

Type

Original Article

Type Code

816

Publication Type

Journal

Publication Title

International Journal of Medical Arts

Publication Link

https://ijma.journals.ekb.eg/

MainTitle

Magnesium Sulfate versus Nitroglycerin in Controlled Hypotensive Anesthesia in Middle Ear Surgeries

Details

Type

Article

Created At

22 Jan 2023