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Comparative Study between Sertraline and Omega-3 Supplementation in The Treatment of Uremic Pruritus in Hemodialysis Patient

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Dermatology

Abstract

Background: Pruritus in uremic patients decreases the quality of life because of sleep disturbances, depression and anxiety, thus, pruritus remains an important health issue in ESRD patients. 
Aim of the work:To evaluate the efficacy and safety of sertraline versus omega 3 supplementation in the treatment of uremic pruritus.
Patients and Methods:This randomized case control study was conducted on patients with ESRD patients .All studied subjects had been collected from the Al-Azhar hospital [Damietta] Dialysis Center. This study had been carried out on 50 patients divided into: Group [A] : consists of 25patients had been received 50 mg sertraline twice a day for 8 weeks. Group [B]: consists of 25 patients and had been receive 3 gm omega-3 daily.
Results: Although pruritus severity decrease significantly in both groups and both scoring systems [P<0.001], the reduction was significantly more in sertraline group [p
Conclusion: Omega-3 fatty acids found to be effective in decreasing of uremic pruritus. So, it seems that Omega-3 fatty acids could be used as an efficient drug for treatment of pruritus in uremic patients. The present study showed that low-dose sertraline was effective for antihistamine-refractory uremic pruritus than omeg3 in renal palliative care patients.

DOI

10.21608/ijma.2020.31065.1127

Keywords

omega-3, Sertraline, pruritus, End-stage renal disease, uremic, renal

Authors

First Name

Mohamed

Last Name

Elghareib

MiddleName

Fathy

Affiliation

Department of Dermatology, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

focus.fathey@gmail.com

City

Mansoura

Orcid

-

First Name

Ibrahim

Last Name

Fouda

MiddleName

-

Affiliation

Department of Dermatology, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

ifouda77@gmail.com

City

-

Orcid

-

First Name

Hassan

Last Name

Khodair

MiddleName

-

Affiliation

Department of Dermatology, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

drhassankhodair@gmail.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Al-Adl

MiddleName

Salama

Affiliation

Department of Internal Medicine, Damietta Faculty of Medicine, Al-Azhar University, Egypt.

Email

salama139@domazhermedicine.edu.eg

City

Mansoura

Orcid

-

Volume

2

Article Issue

3

Related Issue

16043

Issue Date

2020-07-01

Receive Date

2020-05-27

Publish Date

2020-07-01

Page Start

655

Page End

660

Print ISSN

2636-4174

Online ISSN

2682-3780

Article File

IJMA_Volume 2_Issue 3_Pages 655-660.pdf

PDF . 267.2kB

Link

https://ijma.journals.ekb.eg/article_95625.html

Detail API

https://ijma.journals.ekb.eg/service?article_code=95625

Order

25

Type

Original Article

Type Code

816

Publication Type

Journal

Publication Title

International Journal of Medical Arts

Publication Link

https://ijma.journals.ekb.eg/

MainTitle

Comparative Study between Sertraline and Omega-3 Supplementation in The Treatment of Uremic Pruritus in Hemodialysis Patient

Details

Type

Article

Created At

22 Jan 2023