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94398

Effect of Inhaled Corticosteroids on Blood Glucose Homeostasis in Asthmatic Children

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Pediatrics

Abstract

Background: Asthma is a common disease especially in kids. The development of asthma symptoms appears to involve a combination of genetic predisposition and environmental factors. There are many medicines for asthma management, the most important of which is corticosteroid. High doses of inhaled corticosteroids can be associated with hyperglycemia risk increase. 
Aim of the work: To detect the effect of inhaled corticosteroids on blood glucose homeostasis in asthmatic children.
Patients and Methods:This study was conducted at pediatric inpatient and outpatient clinic of New Damietta Al-Azhar University Hospital in the period from September 2018 to September 2019, included 90 asthmatic children chosen randomly, 55 of them were males and 35 of them were females, aged from 2 to 12 years, For each child, the demographic data were collected, divided into three groups according to type of treatment, group I [using ICS only for more than 3 months], group  II [using SCS] and group III [using ICS & SCS].
Results: Regarding WBCs and its differentiation there was a significant increase in WBCs [7.8±2.1] and eosinophil [2.7±0.83]  in [group III] more than [group I]; WBCs [5.8±2.2]  and eosinophil [1.4±0.6] and [group II]; WBCs [6.4±2.0] and eosinophil [1.5±0.7].  Regarding blood glucose, [group I] mean value was [89.6±22.8]; [group II] was [91.6±17.3]; [group III] was [104.4±36.1]. There was statistically significant difference between group I with III and group II with III [P2: 0.032 and P3: 0.043].
Conclusion: Blood glucose level increased in children using both inhaled and systemic corticosteroids and it was significant statistically. 

DOI

10.21608/ijma.2020.22691.1083

Keywords

Corticosteroids, Inhaled, glucose, Asthma, children

Authors

First Name

Alshaimaa

Last Name

Essam

MiddleName

Mohammed

Affiliation

Department of Pediatrics, Faculty of Medicine, Mansura University, Egypt

Email

dr_shin89@yahoo.com

City

biala

Orcid

-

First Name

Mohamed

Last Name

Abdel-Aal

MiddleName

Ibrahim

Affiliation

Department of Pediatrics, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

drabdelaalmo@gmail.com

City

-

Orcid

-

First Name

Hesham

Last Name

Abd Al-samee

MiddleName

Samir

Affiliation

Department of Clinical Pathology, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

dr.hesham012@gmail.com

City

-

Orcid

27608151100155

Volume

2

Article Issue

3

Related Issue

16043

Issue Date

2020-07-01

Receive Date

2020-01-20

Publish Date

2020-07-01

Page Start

645

Page End

649

Print ISSN

2636-4174

Online ISSN

2682-3780

Article File

IJMA_Volume 2_Issue 3_Pages 645-649.pdf

PDF . 243.0kB

Link

https://ijma.journals.ekb.eg/article_94398.html

Detail API

https://ijma.journals.ekb.eg/service?article_code=94398

Order

23

Type

Original Article

Type Code

816

Publication Type

Journal

Publication Title

International Journal of Medical Arts

Publication Link

https://ijma.journals.ekb.eg/

MainTitle

Effect of Inhaled Corticosteroids on Blood Glucose Homeostasis in Asthmatic Children

Details

Type

Article

Created At

22 Jan 2023