Subjects
-Abstract
Background: Allergic rhinitis is one of the most common diseases, with no consensus on its ideal treatment. Botulinum Toxin-A was proposed to be an effective treatment.
Aim of the work: To estimate the outcome of intranasal injection of Botulinum Toxin-A [BTX-A] as a sole therapy for allergic rhinitis.
Patients and Methods:Ninty patients with classic symptoms of allergic rhinitis were clinically evaluated and asked to complete the score for allergic rhinitis [SFAR] questionnaire using cutoff at >8 as diagnostic AR. Two blood samples [venous] and nasal smears were obtained at the beginning of the study and at the end of 12-weeks after initiation of therapy for estimation of human immunoglobulin E [IgE] and eosinophilia grading. Control group included patients who chose to receive combined medical treatment. BTX-A, 2.5 units were injected intranasally, under 0o rigid telescope guidance. Study outcome was the treatment success rate at the end of 12-w follow-up period.
Results: Intranasal BTX-A injection provided significantly maintained relieve of allergic rhinitis manifestations especially for running nose than combination therapy. The treatment success rate of 1.9 versus 0.7 item/patient in study versus control group with significant difference in favor of BTX-A injection. Serum IgE levels and eosinophilia grades were significantly lower in control patients. Patients' satisfaction grading was significantly more with BTX-A injection.
Conclusion: Intranasal BTX injection could be a safe and effective sole therapeutic modality for patients with long-lasting AR
DOI
10.21608/ijma.2020.26878.1113
Keywords
Allergic Rhinitis, Botulinum toxin-A, Intranasal injection, Medical treatment, Score for allergic rhinitis
Authors
MiddleName
-Affiliation
Department of Otorhinolaryngology, Damietta Faculty of Medicine, Al-Azhar University, Egypt
Orcid
-MiddleName
-Affiliation
Otorhinolaryngology Department, Faculty of Medicine, Al-Azhar University, Egypt.
City
-Orcid
-Affiliation
Department of Otorhinolaryngology, Damietta Faculty of Medicine, Al-Azhar University, Egypt.
Email
drashrafwahba70@yahh.com
City
-Orcid
-MiddleName
-Affiliation
Department of Clinical Pathology, Damietta Faculty of Medicine, Al-Azhar University, Egypt.
Email
a.raslan78@gmail.com
City
-Orcid
-Link
https://ijma.journals.ekb.eg/article_97557.html
Detail API
https://ijma.journals.ekb.eg/service?article_code=97557
Publication Title
International Journal of Medical Arts
Publication Link
https://ijma.journals.ekb.eg/
MainTitle
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