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Factors Affecting Nodal Status in Breast Cancer

Article

Last updated: 04 Jan 2025

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Subjects

-

Tags

Surgery

Abstract

Background: Nodal status in breast cancer [BC] is the most prognostic factor for survival and prognosis, and affects treatment decisions. Nodal status had reciprocal relation with pre- and post-operative factors. All these reflect the crucial importance of nodal status in BC.
Aim of the work: Evaluation of pre- and post-operative factors related to nodal status in breast cancer.
Patients and Methods: The current work included 40 patients with confirmed BC, who had been scheduled for modified radical mastectomy or conservative breast surgery with axillary evacuation. All were assessed in a systematic manner preoperatively. In addition, an intraoperative and post-operative evaluation had been carried out. Postoperative histopathological examination of excised tissues had been done for all specimens. Both intra- and post-surgical complications and factors associated with positive nodal status were documented. 
Results: The most significant factors associated with high positive nodal status were age (patient ≤ 45 years was significantly associated with increased positive nodes when compared to > 45 years (37.68±35.23 vs 17.66±19.45 respectively), obesity (30.66±27.33 vs 18.49±25.07 nodes for obese and lean individuals respectively)., tumors greater than 2 cm, positivity of the human-epidermal-growth-factor receptor 2 [Her2]/neu, positive lymphovasular invasion, tumors of the upper quadrant, and the type of histopathology.
Conclusion: Nodal status affected by pre- and post-surgery factors (e.g., age, obesity, tumor site, tumor size, Her2/neu, lymphovascular invasion and histopathological type of the tumor). Thus, these factors help in planning of the treatment such as the type of surgery, endocrine therapy, radiation therapy and the adjuvant chemotherapy.  

DOI

10.21608/ijma.2020.24500.1105

Keywords

Axillary evacuation, breast cancer, Lymph nodes, adjuvant therapy, prognosis

Authors

First Name

Diaa

Last Name

Aboelata

MiddleName

Moahmmed

Affiliation

Department of General Surgery, Tanta Cancer Center, Ministry of Health, Egypt.

Email

dia2_2017@yahoo.com

City

tanta

Orcid

-

First Name

Amr

Last Name

Sarhan

MiddleName

Abdel-ghany

Affiliation

Department of General surgery, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

amr.sarhan32@yahoo.com

City

-

Orcid

-

First Name

Mohammed

Last Name

Abo Mira

MiddleName

Al Sayed

Affiliation

Department of General Surgery, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

dr_mohammed51@yahoo.com

City

mansoura

Orcid

-

First Name

Sami

Last Name

Mohammed

MiddleName

Abdallah

Affiliation

Department of Pathology, Damietta Faculty of Medicine, Al-Azhar University, Egypt.

Email

mdiaa52@yahoo.com

City

Tanta

Orcid

-

Volume

2

Article Issue

3

Related Issue

16043

Issue Date

2020-07-01

Receive Date

2020-02-23

Publish Date

2020-07-01

Page Start

535

Page End

541

Print ISSN

2636-4174

Online ISSN

2682-3780

Article File

IJMA_Volume 2_Issue 3_Pages 535-541.pdf

PDF . 345.7kB

Link

https://ijma.journals.ekb.eg/article_92262.html

Detail API

https://ijma.journals.ekb.eg/service?article_code=92262

Order

7

Type

Original Article

Type Code

816

Publication Type

Journal

Publication Title

International Journal of Medical Arts

Publication Link

https://ijma.journals.ekb.eg/

MainTitle

Factors Affecting Nodal Status in Breast Cancer

Details

Type

Article

Created At

22 Jan 2023