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Predictive Value of both Serum Placental Protein-13 Level and Uterine Artery Doppler for Prediction of Pre-Eclampsia

Article

Last updated: 04 Jan 2025

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Subjects

-

Tags

Gynecology and Obstetrics

Abstract

Background: Preeclampsia [PE] is one of the commonest medical emergencies. It had high morbidity for the mother and her infant. Early diagnosis could reduce such morbidity. 
Aim of the work: To evaluate the role of maternal serum placental protein [PP13] levels and uterine artery Doppler in early prediction and prognosis of preeclampsia.
Patients and Methods: The study included 60 pregnant women in their first and early second trimester with high risk for preeclampsia. Patients were divided into three groups: control, mild and sever preeclampsia. All were subjected to proper history taking, clinical and obstetrical examination, laboratory investigations and ultrasound examination.
Results: Cesarean delivery was significantly increased in preeclampsia compared to controls [55% of mild and 20% of severe disease compared to 15% of controls]. Both uterine artery resistance index [RI] and pulsatility index [PI] were significantly increased in PE when compared to control and in severe when compared to mild PE groups. Finally, PP13 was significantly decreased in patients with severe PE [171.7±35.9] when compared to mild PE [213.1±41.8] or control group [254.8±51.1]. In addition, there was significant decrease in cases with mild PE when compared to control group. Finally, there was inverse [negative], moderate and statistically significant correlation between PP-13 from one side and each of systolic BP, diastolic BP, uterine artery RI and PI. In addition, both RI and PI were proportionally correlated with PI and RI.
Conclusion: The present study showed that PP13 combined with PI or RI can predict PE with a good sensitivity and specificity. 

DOI

10.21608/ijma.2020.22342.1081

Keywords

preeclampsia, Placental Protein-13, uterine artery, Doppler, prediction

Authors

First Name

Marwa

Last Name

El-hassab

MiddleName

Samir

Affiliation

Department of Obstetrics and Gynecology, Sammanoud General Hospital, Ministry of Health, Egypt.

Email

mzattia11@gmail.com

City

sammanoud

Orcid

0000-0002-3289-442X

First Name

Rashed Mohamed

Last Name

Rashed

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

rmrashed70@yahoo.com

City

-

Orcid

-

First Name

Magdy

Last Name

Elghannam

MiddleName

Zaky

Affiliation

Department of Clinical Pathology, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

mzm.alghannam@domazhermedicine.edu.eg

City

Mansoura

Orcid

-

First Name

Alaa Eldin

Last Name

Megahed

MiddleName

Mahmoud

Affiliation

Department of Obstetrics and Gynecology, Damietta Faculty of Medicine, Al-Azhar University, Egypt

Email

dr.alaamegahed@domazhermedicine.edu.eg

City

Damietta

Orcid

-

Volume

2

Article Issue

3

Related Issue

16043

Issue Date

2020-07-01

Receive Date

2020-01-12

Publish Date

2020-07-01

Page Start

528

Page End

534

Print ISSN

2636-4174

Online ISSN

2682-3780

Article File

IJMA_Volume 2_Issue 3_Pages 528-534.pdf

PDF . 326.9kB

Link

https://ijma.journals.ekb.eg/article_93181.html

Detail API

https://ijma.journals.ekb.eg/service?article_code=93181

Order

6

Type

Original Article

Type Code

816

Publication Type

Journal

Publication Title

International Journal of Medical Arts

Publication Link

https://ijma.journals.ekb.eg/

MainTitle

Predictive Value of both Serum Placental Protein-13 Level and Uterine Artery Doppler for Prediction of Pre-Eclampsia

Details

Type

Article

Created At

22 Jan 2023