Beta
ManageSearchChatDiscover
67647

Plasma Homocysteine Level in Children under Treatment with Antiepileptic Drugs and its Relation to Intelligence Quotient

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Pediatrics

Abstract

Background: Epilepsy is one of the most common neurological disorders in children. It often requires long-term antiepileptic drug (AED) therapy. AEDs are frequently associated with cognitive and behavioral dysfunctions. Also, there is a relationship between AEDs use and homocysteine levels. Elevated homocysteine has been associated with cognitive dysfunction. However, such effect among epileptic children has not been well-studied.
Aim of the work: To study plasma homocysteine level in children under treatment with AEDs and its relation to intelligence quotient (IQ).
Patients and Methods: A case control study included 56 epileptic children on AED therapy for at least 6 months, and 36 healthy children (Controls). Study was conducted at Al-Azhar University Hospital (Damietta) from June 2016 to June 2018. Plasma homocysteine was measured using Enzymatic Recycling (Biotecnica Instruments SpA). IQ testing was conducted using Stanford-Binet Intelligence Scales, Fifth Edition.
Results: Epileptic children exhibited significant elevation of Homocysteine level (P=0.005), and significant affection of all IQ parameters. There was significant negative correlation between homocysteine level with total working memory, total verbal IQ and total IQ. Multivariate regression analysis revealed that homocysteine showed a significant and independent association with total working memory, total verbal IQ and total IQ. None of the other studied factors revealed such association.
Conclusion: Homocysteine was a significant and independent risk factor for low total working memory score, low total Verbal IQ and low total IQ scores. Further studies are required to confirm these results, and to evaluate the effect of homocysteine-lowering treatment on cognitive function in epileptic children.

DOI

10.21608/ijma.2020.16455.1029

Keywords

Epilepsy, Antiepileptic drugs, Homocysteine, Cognition, Intelligence Quotient

Authors

First Name

Mohammed

Last Name

Abo Al-maaty

MiddleName

-

Affiliation

Pediatric department, Al-Azhar University, New Damietta

Email

maboalmaaty1984@gmail.com

City

-

Orcid

0000-0002-9125-5345

First Name

Mohamed

Last Name

Elmazahy

MiddleName

-

Affiliation

Pediatric Department, Al-Azhar Faculty of Medicine (Damietta)

Email

m_mazahi@hotmail.com

City

-

Orcid

-

First Name

Tarek

Last Name

Emran

MiddleName

Mustafa

Affiliation

Professor of Clinical Pathology, Al-Azhar Faculty of Medicine (Damietta)

Email

drtarekemran@gmail.com

City

Damietta

Orcid

0000-0002-8893-2579

First Name

Hany

Last Name

El-khaleegy

MiddleName

-

Affiliation

Al-Azhar University, Pediatric Department (Damietta)

Email

hanykhaleegy@yahoo.com

City

-

Orcid

-

Volume

2

Article Issue

1

Related Issue

10770

Issue Date

2020-01-01

Receive Date

2019-09-15

Publish Date

2020-01-01

Page Start

223

Page End

231

Print ISSN

2636-4174

Online ISSN

2682-3780

Article File

IJMA_Volume 2_Issue 1_Pages 223-231.pdf

PDF . 359.6kB

Link

https://ijma.journals.ekb.eg/article_67647.html

Detail API

https://ijma.journals.ekb.eg/service?article_code=67647

Order

12

Type

Original Article

Type Code

816

Publication Type

Journal

Publication Title

International Journal of Medical Arts

Publication Link

https://ijma.journals.ekb.eg/

MainTitle

Plasma Homocysteine Level in Children under Treatment with Antiepileptic Drugs and its Relation to Intelligence Quotient

Details

Type

Article

Created At

22 Jan 2023