Within three years investigation (2020 – 2022), 50 cattle in Sohag Governorate, South Egypt, were necropsied due to severe respiratory manifestations. Their lungs were grossly and histopathologically monitored, and culturally examined for detection of pus-forming pathogens. All examined cattle were unvaccinated against respiratory viral pathogens. Lung-sequestrations with whitish-yellow purulent and/or caseated masses with necrosis of deep tissues was the topmost necropsy finding. The lung appeared as an edematous structure containing yellowish caseated purulent materials with demarcation of the interlobular septae. Histopathologically, the interlobular septae were filled with fibrinous exudate with fibrinopurulent inflammation in alveolar tissue. Bacteriologically, Trueperella pyogenes followed by Staphylococcus aureus, β hemolytic streptococci and non-hemolytic short chain cocci were culturally isolated with frequency percentage of 100%, 42.00%, 18.00% and 18.00%, respectively. The highest frequent isolation of Trueperella pyogenes from the deep pulmonary tissues may symbolize the existence of an enabling factor facilitate the pathway to deep pulmonary tissues by damaging the lung defense mechanism. Similarly, Staphylococcus aureus, hemolytic streptococci, and non-hemolytic short chain cocci are also pus-forming pathogens and they follow the same path of Trueperella pyogenes. The existence of pyogenic pathogens increased the seriousness of pneumonias in cattle and declined the chances of successful therapy. The prime enabling agents that facilitate the pathway of pyogenic microbes to invade the deep respiratory system should screened. Cattle should regularly vaccinated against the respiratory pathogens deterring the lung clearance mechanism to reduce the existence of pyogenic pathogens. Investigation on role of respiratory viruses and mycoplasmas in pneumonias are crucially reasonable.